Effects of surface area to volume ratio of PLGA scaffolds with different architectures on scaffold degradation characteristics and drug release kinetics
Effects of surface area to volume ratio of PLGA scaffolds with different architectures on scaffold degradation characteristics and drug release kinetics
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DOI：
10.1002/jbm.a.35657
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发表时间：
2016-05-01
影响因子：
4.9
通讯作者：
Hinojosa, Victor A.
中科院分区：
文献类型：
--
作者：
Chew, Sue Anne;Arriaga, Marco A.;Hinojosa, Victor A.
本文以米诺环素为模型药物，制备了不同构型的PLGA支架，考察了不同构型所产生的比表面积体积比(SVR)对支架降解特性和药物释放动力学的影响。假设具有最高SVR的细链支架的降解速度比粗股和球状支架更快，因为表面积的增加将允许水分子与聚合物中可降解的酯基之间有更多的接触。然而，研究发现，SVR最低的球形支架降解最快，这表明支架的降解量不仅取决于SVR，还取决于支架中酸性降解副产物的滞留和支架孔隙率等其他因素。PLGA 50：50球形支架具有双相释放，在释放研究的开始和中期出现突释，这可能有利于某些药物的释放。未观察到药物释放速率与SVR之间的明显相关性，表明除了有更大的药物扩散出聚合物基质的表面积外，支架降解量和支架孔隙率等其他因素可能在决定药物释放动力学中起作用。未来还需要进行进一步的研究，如扫描电子显微镜，以进一步评估支架的孔隙率、形态和结构。(C)2016 Wiley期刊，Inc.生物材料资源A部分：104A：1202-1211,2016。
In this work, PLGA scaffolds with different architectures were fabricated to investigate the effects of surface area to volume ratio (SVR) (which resulted from the different architectures) on scaffold degradation characteristics and drug release kinetics with minocycline as the model drug. It was hypothesized that the thin strand scaffolds, which had the highest SVR, would degrade faster than the thick strand and globular scaffolds as the increase in surface area will allow more contact between water molecules and degradable ester groups in the polymer. However, it was found that globular scaffolds, which had the lowest SVR, resulted in the fastest degradation which demonstrated that the amount of degradation of the scaffolds does not only depend on the SVR but also on other factors such as the retention of acidic degradation byproducts in the scaffold and scaffold porosity. PLGA 50 : 50 globular scaffolds resulted in a biphasic release profile, with a burst release in the beginning and the middle of the release study which may be beneficial for some drug delivery applications. A clear correlation between SVR and release rates was not observed, indicating that besides the availability of more surface area for drug to diffuse out of the polymer matrix, other factors such as amount of scaffold degradation and scaffold porosity may play a role in determining drug release kinetics. Further studies, such as scanning electron microscopy, need to be performed in the future to further evaluate the porosity, morphology and structure of the scaffolds. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1202-1211, 2016.