Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions.
Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions.
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DOI：
10.1186/s13048-015-0202-y
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发表时间：
2015-11-14
影响因子：
4
通讯作者：
Yoshida Y
中科院分区：
文献类型：
--
作者：
Hattori Y;Yamada S;Yamamoto M;Orisaka M;Mizutani T;Yoshida Y
在患有具有功能性间质的常见上皮性卵巢肿瘤的绝经后妇女中，偶尔会检测到高血清雌二醇（E2）水平。已证明，功能性基质具有将雄激素转化为雌激素的能力。然而，功能基质的起始和发育机制仍不清楚。我们介绍了两例患有卵巢粘液腺癌且含有功能性基质的老年女性 E2 水平升高的病例。免疫组织化学评估显示，卵巢基质中芳香酶和类固醇生成因子 1 (SF-1) 的高表达水平，SF-1 被认为是类固醇生成的主要调节因子。这些病例表明，SF-1 的过度表达可能通过调节具有功能性基质的卵巢肿瘤中 P450 芳香酶的表达来促进雌激素生物合成。这反过来会导致患有常见上皮性卵巢肿瘤的绝经后妇女血清 E2 水平升高。
A high serum estradiol (E2) level is occasionally detected in postmenopausal women with common epithelial ovarian tumors with functioning stroma. It has been proven that functioning stroma has the capacity to convert androgens to estrogens. However, the mechanism of the initiation and development of functioning stroma remains unclear. We present two cases of elevated E2 levels in elderly women with ovarian mucinous adenocarcinomas that contained functioning stroma. Immunohistochemical evaluation revealed high expression levels of aromatase and steroidogenic factor-1 (SF-1), which is considered to be a master regulator of steroidogenesis, in their ovarian stroma. These cases suggest that overexpression of SF-1 may promote estrogen biosynthesis through regulation of P450 aromatase expression in ovarian tumors with functioning stroma; this in turn induces high serum E2 levels in postmenopausal women with common epithelial ovarian tumors.