Three new antibacterial active diarylheptanoids from Alpinia officinarum
Three new antibacterial active diarylheptanoids from Alpinia officinarum
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三种来自高良姜的新型抗菌活性二芳基庚烷类化合物
DOI：
10.1016/j.fitote.2010.06.015
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发表时间：
2010-10-01
期刊：
影响因子：
3.4
通讯作者：
Ding, Li-Sheng
中科院分区：
文献类型：
--
作者：
Zhang, Bei-Bei;Dai, Yuan;Ding, Li-Sheng
从高良姜根茎的乙醇提取物中分离出三种新的二芳基庚烷类化合物以及十种已知的二芳基庚烷类化合物。这些化合物的结构鉴定主要通过光谱方法实现。新化合物分别被阐明为7-(4'', 5''-二羟基-3''-甲氧基苯基)-1-苯基-4-庚烯-3-酮(1)、1, 7-二苯基-5-庚烯-3-酮(2)和4-苯乙基-1, 7-二苯基-1-庚烯-3, 5-二酮(3)。所有化合物均表现出针对幽门螺杆菌的抗菌活性。特别是，这三种新化合物对Hp-Sydney菌株1表现出较强的抗菌活性，MIC值为9-12μg/mL，对Hp-F44表现出较强的抗菌活性，MIC值为2530μg/mL。 (C) 2010 Elsevier B.V. 保留所有权利。
Three new diarylheptanoids, together with ten known ones, were isolated from the ethanol extract from the rhizomes of Alpinia officinarum Hance. The structural identification of these compounds was mainly achieved by spectroscopic methods. The new compounds were elucidated as 7-(4 '', 5 ''-dihydroxy-3 ''-methoxyphenyl)-1-phenyl -4-heptene-3-one (1), 1, 7-diphenyl-5-heptene-3-one (2) and 4-phenethyl-1, 7-diphenyl -1-heptene-3, 5-dione (3), respectively. All of the compounds showed antibacterial activity against Helicobactor pylori. Especially, the three new compounds showed strong antibacterial activity against Hp-Sydney strain 1 with the MIC values of 9-12 mu g/mL, and against Hp-F44 with the MIC values of 2530 mu g/mL. (C) 2010 Elsevier B.V. All rights reserved.