Growth hormone prevents neuronal loss in the aged rat hippocampus
Growth hormone prevents neuronal loss in the aged rat hippocampus
复制标题
DOI：
10.1016/j.neurobiolaging.2004.06.007
复制
发表时间：
2005-05-01
影响因子：
4.2
通讯作者：
Tresguerres, JAR
中科院分区：
文献类型：
--
作者：
Azcoitia, I;Perez-Martin, M;Tresguerres, JAR
Decline of growth hormone (GH) with aging is associated to memory and cognitive alterations. In this study, the number of neurons in the hilus of the dentate gyrus has been assessed in male and female Wistar rats at 3, 6, 12, 14, 18, 22 and 24 months of age, using the optical fractionator method. Male rats had more neurons than females at all the ages studied. Significant neuronal loss was observed in both sexes between 22 and 24 months of age. In a second experiment, 22 month-old male and female rats were treated for 10 weeks with 2 mg/kg/day of GH or saline. At 24 months of age, animals treated with GH had more neurons in the hilus than animals treated with saline. These findings indicate that GH is neuroprotective in old animals and that its administration may ameliorate neuronal alterations associated to aging. (C) 2004 Elsevier Inc. All rights reserved.
