A cutoff in potency exists in the perfluoroalkanes.
A cutoff in potency exists in the perfluoroalkanes.
复制标题
全氟烷烃存在效力截止。
DOI：
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发表时间：
1994
影响因子：
5.7
通讯作者：
B. Chortkoff
中科院分区：
文献类型：
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作者：
J. Liu;M. Laster;D. Koblin;E. Eger;M. Halsey;S. Taheri;B. Chortkoff
在雄性大鼠中评估从全氟甲烷到全氟辛烷的全氟烷烃的麻醉效力（最小肺泡麻醉浓度[MAC]），以确定麻醉作用的截止值（即，不存在任何麻醉作用）。虽然高压测量表明CF 4的MAC为38.9 +/- 6 atm（平均值+/- SD），但该压力几乎与致死压力41.1 +/- 5.8 atm相同。C2 F6的高压研究在不引起麻醉的情况下导致死亡，致死压力为23.8 +/- 2.6 atm。地氟烷的加和性研究结果表明，在平均CF 4测试分压为17.7 +/- 4.0 atm时，CF 4的MAC为66.5 +/- 13.4 atm（即，17.7大气压的CF_4使地氟醚的MAC降低26.6%。地氟烷、异氟烷或氟烷的加和性研究未显示C2 F6在7.2 +/- 0.4 atm压力下的麻醉作用，或较大的全氟烷烃接近或处于其饱和蒸气压下的麻醉作用。我们的结论是，全氟烷烃的麻醉效力之间存在一个截止全氟甲烷和全氟乙烷。
Anesthetic potencies (minimum alveolar anesthetic concentration [MAC]) of perfluoroalkanes from perfluoromethane to perfluorooctane were assessed in male rats to determine whether a cutoff in anesthetic effect (i.e., an absence of any anesthetic effect) exists for the larger compounds in this series. Although hyperbaric measurements suggested a MAC of 38.9 +/- 6 atm (mean +/- SD) for CF4, this pressure was nearly identical to the lethal pressure of 41.1 +/- 5.8 atm. Hyperbaric studies of C2F6 caused death without causing anesthesia, the lethal pressure being 23.8 +/- 2.6 atm. Results from studies of additivity with desflurane suggested that the MAC of CF4 was 66.5 +/- 13.4 atm at an average CF4 test partial pressure of 17.7 +/- 4.0 atm (i.e., 17.7 atm of CF4 decreased the MAC of desflurane by 26.6%). Studies of additivity with desflurane, isoflurane, or halothane did not reveal an anesthetic effect of C2F6 at a pressure of 7.2 +/- 0.4 atm, or of larger perfluoroalkanes near to or at their saturated vapor pressures. We conclude that a cutoff in anesthetic potency for perfluoroalkanes exists between perfluoromethane and perfluoroethane.