Conservation of Pax gene expression in ectodermal placodes of the lamprey
Conservation of Pax gene expression in ectodermal placodes of the lamprey
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DOI：
10.1016/s0378-1119(01)00894-0
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发表时间：
2002-04-03
期刊：
影响因子：
3.5
通讯作者：
Bronner-Fraser, M
中科院分区：
文献类型：
--
作者：
McCauley, DW;Bronner-Fraser, M
外胚层基板构成颅神经节和头部的感觉器官，并与神经嵴细胞一起代表脊椎动物胚胎的决定性特征。Pax基因的表达不同可能决定了不同基板的同源性，Pax 3/7类基因在小鼠、鸡、青蛙和鱼的三叉基因基板上表达，Pax 2/5/8类基因在三叉基因基板上表达。在此，我们介绍了七鳃鳗Pax-7和Pax-2的克隆和表达模式，它们分别标记三叉和耳基板，以及脊椎动物Pax基因的其他特征结构。这些结果表明Pax基因和placodal结构在基础和衍生脊椎动物中保存。(C) 2002 Elsevier Science B.V.版权所有
Ectodermal placodes contribute to the cranial ganglia and sense organs of the head and, together with neural crest cells, represent defining features of the vertebrate embryo. The identity of different placodes appears to be specified in part by the expression of different Pax genes, with Pax-3/7 class genes being expressed in the trigeminal placode of mice, chick, frogs and fish, and Pax-2/5/8 class genes expressed in the otic placode. Here, we present the cloning and expression pattern of lamprey Pax-7 and Pax-2, which mark the trigeminal and otic placodes, respectively, as well as other structures characteristic of vertebrate Pax genes. These results suggest conservation of Pax genes and placodal structures in basal and derived vertebrates. (C) 2002 Elsevier Science B.V. All rights reserved.