Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation
Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation
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DOI：
10.1016/j.vaccine.2008.09.076
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发表时间：
2008-12-09
期刊：
影响因子：
5.5
通讯作者：
Nakayama, Tetsuo
中科院分区：
文献类型：
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作者：
Shinjoh, Masayoshi;Miyairi, Isao;Nakayama, Tetsuo
由于其理论风险，不建议肝移植后儿童使用减毒活疫苗进行免疫接种。然而，当他们回到现实生活中时，他们会遇到疫苗可预防的病毒性疾病。我们对18例符合临床标准（包括体液免疫和细胞介导免疫）的儿童活体供者肝移植（LDLT）后接受者进行了总计70次免疫接种，其中包括4种减毒活疫苗。麻疹（株AIK-C）、风疹（株TO-336）、水痘（株Oka）和腮腺炎（株Hoshino）的首次接种的血清转化率分别为100%（15/15）、100%（15/15）、82%（9/11）和82%（9/11）。在观察期间（-5年11个月），除了风疹免疫接种后，观察到少数免疫力下降的病例（抗体一度产生，但水平随时间下降）。未观察到血清转换后的临床疾病或明确的免疫严重不良反应。使用选定的减毒活疫苗进行免疫接种对于LDLT后未出现严重免疫抑制的儿童是安全有效的。(C)2008爱思唯尔有限公司保留所有权利。
Immunizations using live-attenuated vaccines are not recommended for post-liver transplant children due to its theoretical risks. However, they will encounter vaccine-preventable viral diseases upon returning to real-life situations. We performed a total of 70 immunizations with four individual live-attenuated vaccines to 18 pediatric post-living donor liver transplant (LDLT) recipients who fulfilled a clinical criteria including humoral and cell-mediated immunity. the seroconversion rates at the first dose of measles (strain AIK-C), rubella (strain TO-336), varicella (strain Oka), and mumps (strains Hoshino) were 100% (15/15), 100% (15/15), 82% (9/11), and 82% (9/11), respectively. During observed period (-5 years 11 months), a few cases with waning immunity (antibodies were once produced but the levels fell over time) were seen except after rubella immunization. Clinical diseases after seroconversion or definite serious adverse effects due to immunization were not observed. Immunizations using selected live-attenuated vaccines were safe and effective for post-LDLT children who were not severely immunosuppressed. (C) 2008 Elsevier Ltd. All rights reserved.