Immune suppression of erythropoiesis in transient erythroblastopenia of childhood.
Immune suppression of erythropoiesis in transient erythroblastopenia of childhood.
复制标题
儿童短暂性红细胞减少症中红细胞生成的免疫抑制。
DOI：
10.1182/blood.v54.3.742.bloodjournal543742
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发表时间：
1979
期刊：
影响因子：
20.3
通讯作者：
L. Diamond
中科院分区：
文献类型：
--
作者：
H. Koenig;A. Lightsey;Dennis P. Nelson;L. Diamond
本文对4例儿童期短暂性红细胞减少症（TEC）患儿的血清和IgG进行了检测，以观察其对骨髓单核细胞形成红细胞菌落的影响。诊断时获得的血清和IgG标本均可抑制CFU-E的红系菌落发育。一个患有TEC的儿童的骨髓单个核细胞在他自己的血清中不能生长，但在同种血清中生长正常。从TEC患者恢复后获得的血清标本对红系菌落发育无影响。TEC的贫血似乎是由于红细胞集落发育的短暂免疫抑制。
Serum and IgG from four children with transient erythroblastopenia of childhood (TEC) was tested to see what effect it would have on development of erythroid colonies from bone marrow mononuclear cells. Serum and IgG specimens obtained at the time of diagnosis uniformly suppressed erythroid colony development from CFU-E. Washed bone marrow mononuclear cells from a child with TEC failed to grow in the presence of his own serum, but grew normally in the presence of isologous serum. Serum specimens obtained from patients after recovery from TEC had no effect on erythroid colony development. The anemia of TEC appears to be due to transient immune suppression of erythroid colony development.