Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
复制标题
DOI：
10.3945/ajcn.110.005611
复制
发表时间：
2011-02-01
影响因子：
7.1
通讯作者：
Mittendorfer, Bettina
中科院分区：
文献类型：
--
作者：
Smith, Gordon I.;Atherton, Philip;Mittendorfer, Bettina
背景：随着年龄的增长，肌肉质量的损失是一个主要的公共卫生问题。Omega-3（n-3）脂肪酸可刺激动物体内的蛋白质合成，因此可用于治疗肌肉减少症。然而，omega-3脂肪酸对人体蛋白质代谢的影响是unknown.Objective：本研究的目的是评估omega-3脂肪酸补充剂对老年人肌肉蛋白质合成率的影响。设计：16名健康的老年人被随机分配接受8周的omega-3脂肪酸或玉米油。肌肉蛋白质的合成率和合成代谢信号通路的关键元素的磷酸化进行了评估之前和之后的基础，吸收后的条件下，并在hyperaminoacidemic-hyperinsulinemic clamp.Results补充玉米油没有影响肌肉蛋白质的合成率和肌肉中的合成代谢信号元件磷酸化的程度。补充Omega-3脂肪酸对肌肉蛋白质合成的基础速率没有影响（平均6SEM：0.051 +/- 0.005%/h，与补充前和补充后的0.053 +/- 0.008%/h相比; P = 0.80），但增强了高氨基酸血症-高胰岛素血症诱导的肌肉蛋白质合成速率的增加（从基础值以上0.009 +/- 0.005%/h至基础值以上0.031 +/- 0.003%/h; P < 0.01），这伴随着肌肉mTOR（Ser 2448）的更大增加结论：Omega-3脂肪酸可促进老年人肌肉蛋白质合成，对预防和治疗肌肉减少症有一定的作用。该试验在临床试验中注册。编号为NCT 00794079。美国临床营养杂志2011;93：402-12。
Background: Loss of muscle mass with aging is a major public health concern. Omega-3 (n-3) fatty acids stimulate protein anabolism in animals and might therefore be useful for the treatment of sarcopenia. However, the effect of omega-3 fatty acids on human protein metabolism is unknown.Objective: The objective of this study was to evaluate the effect of omega-3 fatty acid supplementation on the rate of muscle protein synthesis in older adults.Design: Sixteen healthy, older adults were randomly assigned to receive either omega-3 fatty acids or corn oil for 8 wk. The rate of muscle protein synthesis and the phosphorylation of key elements of the anabolic signaling pathway were evaluated before and after supplementation during basal, postabsorptive conditions and during a hyperaminoacidemic-hyperinsulinemic clamp.Results: Corn oil supplementation had no effect on the muscle protein synthesis rate and the extent of anabolic signaling element phosphorylation in muscle. Omega-3 fatty acid supplementation had no effect on the basal rate of muscle protein synthesis (mean 6 SEM: 0.051 +/- 0.005%/h compared with 0.053 +/- 0.008%/h before and after supplementation, respectively; P = 0.80) but augmented the hyperaminoacidemia-hyperinsulinemia-induced increase in the rate of muscle protein synthesis (from 0.009 +/- 0.005%/h above basal values to 0.031 +/- 0.003%/h above basal values; P < 0.01), which was accompanied by greater increases in muscle mTOR(Ser2448) (P = 0.08) and p70s6k(Thr389) (P < 0.01) phosphorylation.Conclusion: Omega-3 fatty acids stimulate muscle protein synthesis in older adults and may be useful for the prevention and treatment of sarcopenia. This trial was registered at clinical trials. gov as NCT00794079. Am J Clin Nutr 2011;93:402-12.