Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significance
Arterial geometry, flow pattern, wall shear and mass transport: potential physiological significance
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DOI：
10.1098/rsif.2008.0417
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发表时间：
2009-06-06
影响因子：
3.9
通讯作者：
Caro, C.
中科院分区：
文献类型：
--
作者：
Coppola, G.;Caro, C.
我们已经研究了数值稳定和不稳定的流动，在直和螺旋支架颈总动脉，为了模拟猪的实验结果，显示减少内膜增生（IH）的螺旋状的情况下。流动脉动性和三维性的组合产生迪恩涡流的扫掠运动，其总体上降低了到血管壁的氧通量和壁剪切应力（WSS）两者的极值。由于IH和动脉粥样硬化优先影响低WSS区域，这些发现意味着血管三维和血流脉动性在这些疾病中可以发挥重要的保护作用。速度波形的幅值和频率是系统的重要参数。振幅的增加增加了WSS和到血管壁的氧通量。频率的增加有一个小的影响，它增加了WSS，但对血管壁的氧通量没有影响。
We have studied numerically steady and unsteady flow in a straight and a helically stented common carotid artery, in order to model porcine experimental results that show reduced intimal hyperplasia (IH) in the helical case. The combination of flow pulsatility and three-dimensionality generates a sweeping motion of the Dean vortices, which overall reduced extremes of both oxygen flux to the vessel wall and wall shear stress (WSS). Since IH and atherosclerosis affect preferentially low WSS regions, these findings imply that vessel three-dimensionality and flow pulsatility can play important protective roles in respect of these diseases. The amplitude and frequency of the velocity waveform are important parameters of the system. Increase in amplitude increases WSS and oxygen flux to the vessel wall. Increase in frequency has a small effect; it increases WSS but has no effect on the oxygen flux to the vessel wall.