Chronic alcohol treatment results in disturbed vitamin D metabolism and skeletal abnormalities in rats.
Chronic alcohol treatment results in disturbed vitamin D metabolism and skeletal abnormalities in rats.
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长期饮酒会导致大鼠维生素 D 代谢紊乱和骨骼异常。
DOI：
10.1111/j.1530-0277.1988.tb00152.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Bell,NH
中科院分区：
文献类型：
--
作者：
Turner,RT;Aloia,RC;Segel,LD;Hannon,KS;Bell,NH
研究了慢性饮酒对大鼠骨骼的影响。治疗组在流质饮食(舒斯塔卡)中摄入38%卡路里的乙醇，为期10个月。在整个研究过程中，对照组大鼠与酒精处理组动物配对称重；两组大鼠的生长曲线是相同的。对照组给予相同的流质饮食，只是用等量的糊精：麦芽糖(3：1)代替乙醇。乙醇处理的大鼠在平均血钙、磷或肌酐方面与配对加权的对照组没有区别。相比之下，酒精处理的大鼠血清镁含量降低(p<；0.02)。乙醇处理还引起血清维生素D代谢物浓度的变化，血清1，25-羟基维生素D3浓度升高(p<；0.001)，血清1，25-二羟基维生素D3浓度降低(p<；0.01)。酒精处理的大鼠胫骨长度缩短(p<；0.05)，但股骨长度没有变化。与体重匹配的对照组动物相比，酒精处理的大鼠的胫骨骨干髓质面积增加(p<；0.01)，表明吸收的净增加。乙醇处理组大鼠胫骨骨干横截面积与对照组相同。与对照组(p<；0.05)相比，酒精处理组大鼠的胫骨干骺端松质骨减少，这表明骨小梁的净丢失。乙醇处理对股骨的组织重量没有影响，但降低了灰重(p<；0.02)。这些研究表明，慢性酒精处理导致大鼠维生素D代谢紊乱，骨吸收增加，骨基质矿化减少。
The effect of chronic alcohol consumption on the skeleton was Investigated in rats. The treated group received ethanol administered as 38% of caloric intake in a liquid diet (Sustacal) for 10 months. The control rats were pair weighted to the ethanol‐treated animals throughout the study; the growth curves of the two groups were the same. The controls were given the same liquid diet except that dextrin: maltose (3:1) was substituted isocalorically for ethanol. Ethanol‐treated rats did not differ from the pair‐weighted controls in mean serum calcium, phosphorous, or creatinine. In contrast, serum magnesium was reduced (p< 0.02) in alcohol‐treated rats. Ethanol treatment also resulted in changes in the serum concentrations of vitamin D metabolites serum 1,25‐hydroxyvitamin D3was increased (p< 0.001), while serum 1,25‐dihydroxyvitamin D3was decreased (p< 0.01). Tibial length was reduced in ethanol‐treated rats (p< 0.05) but there was no change in femoral length. Medullary area was Increased in tibial diaphyses from alcohol‐treated rats compared to weight matched control animals (p< 0.01), indicating a net increase in resorption. The cross‐sectional area of the tibial diaphysis of ethanol‐treated rats was the same as the matched controls. Trabecular bone was decreased in the tibial metaphysis of ethanol‐treated rats compared to the matched controls (p < 0.05) indicating a net loss of trabecular bone. Ethanol treatment did not have an effect on the organic weight of the femur but the ash weight was reduced (p< 0.02). These studies demonstrate that chronic alcohol treatment in rats results in disturbed vitamin D metabolism, a net increase in bone resorption and decreased mineralization of bone matrix.