FASTING PLASMA-GLUCOSE AND INSULIN LEVELS AND THEIR RELATIONSHIP TO CARDIOVASCULAR RISK-FACTORS IN CHILDREN - BOGALUSA HEART-STUDY
FASTING PLASMA-GLUCOSE AND INSULIN LEVELS AND THEIR RELATIONSHIP TO CARDIOVASCULAR RISK-FACTORS IN CHILDREN - BOGALUSA HEART-STUDY
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DOI：
10.1016/0026-0495(86)90135-6
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发表时间：
1986-05-01
影响因子：
9.8
通讯作者：
BERENSON, GS
中科院分区：
文献类型：
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作者：
BURKE, GL;WEBBER, LS;BERENSON, GS
对 3313 名 5-17 岁混血儿童的血浆葡萄糖和胰岛素水平进行了测定。与同等年龄和性别的白人儿童相比，黑人儿童的胰岛素水平明显较高，而血糖水平明显较低。父母患有糖尿病的孩子的空腹胆固醇水平随年龄和体重的调整而升高。 3 年期间血糖水平的中等跟踪（r = 0.31）被观察到。然而，只有年龄较大的儿童（初次检查时年龄为 9-14 岁）的胰岛素水平跟踪良好（r = 0.36）。空腹胰岛素水平与肥胖、收缩压和舒张压、甘油三酯、β-脂蛋白胆固醇和前β-脂蛋白胆固醇水平的测量结果呈正相关。此外，胰岛素水平与α-脂蛋白胆固醇水平负相关。空腹血糖水平与收缩压和舒张压、甘油三酯、前β-脂蛋白胆固醇和肥胖水平呈正相关。血浆葡萄糖和胰岛素水平与儿童传统心血管危险因素的关系强调了碳水化合物代谢的微妙异常在心血管疾病早期自然史中的重要性。
Plasma glucose and insulin levels were determined in a total biracial community of 3313 children, ages 5-17 years. Black children have significantly higher insulin and lower glucose levels than white children of comparable age and sex. Children of diabetic parents gave elevated levels of age- and weight-adjusted fasting cholesterol. Moderate tracking (r = 0.31) of glucose levels over a 3-year period was seen. Insulin levels, however, track well (r = 0.36) only in older children (ages 9-14 years at initial examination). Fasting insulin levels are positively related to measures of obesity, systolic and diastolic blood pressure, triglyceride, .beta.-lipoproten cholesterol and pre-.beta.-lipoprotein cholesterol levels. In addition, insulin levels are negatively related to .alpha.-lipoprotein cholesterol levels. Fasting glucose levels are positively related to systolic and diastolic blood pressure, triglycerides, pre-.beta.-lipoprotein cholesterol, and obesity levels. The relationship of plasma glucose and insulin levels to the traditional cardiovascular risk factors in children emphasizes the importance of subtle abnormalities in carbohydrate metabolism in the early natural history of cardiovascular disease.