Acquisition of resistance against Fasciola gigantica by Indonesian thin tail sheep.
Acquisition of resistance against Fasciola gigantica by Indonesian thin tail sheep.
复制标题
印度尼西亚细尾羊获得对巨片吸虫的抵抗力。
DOI：
10.1016/s0304-4017(97)00119-2
复制
发表时间：
1997
影响因子：
2.6
通讯作者：
T. Spithill
中科院分区：
文献类型：
--
作者：
J. Roberts;E. Estuningsih;E. Wiedosari;T. Spithill
攻击感染后两到三周内，GLDH的血浆水平以及肝脏表面病变数量和寄生虫数量的发展动态表明，印度尼西亚细尾（ITT）羊获得了对巨片形吸虫的高抵抗力的主要成分，并对幼年寄生虫产生了作用。很少有寄生虫到达 ITT（暴露的）羊的肝脏，但许多寄生虫都被抑制了，可能在空肠壁中。感染后三周，与对照美利奴羊相比，ITT（未接触过的）羊表现出一定的抵抗力。通过给予免疫抑制剂地塞米松，ITT（暴露的）羊的抵抗力表现受到抑制。感染后 21 至 28 天，ITT 绵羊体内寄生虫的杀灭似乎已停止。获得性抗性的基础被认为是 ITT 绵羊对巨型 F. gigantica 特有的抗原或免疫抑制剂做出反应的特殊免疫能力。这种由幼年寄生虫产生的分子值得进一步研究作为疫苗的候选者。
The plasma levels of GLDH and the dynamics of development of the numbers of surface lesions on livers, and numbers of parasites, within two to three weeks of a challenge infection, indicated that the major component of the high resistance of Indonesian thin tail (ITT) sheep against Fasciola gigantica was acquired, and acted against juvenile parasites. Few parasites reached the livers of ITT (exposed) sheep, but many had been inhibited, probably in the wall of the jejunum. ITT (naive) sheep showed some resistance, compared with control Merino sheep, by three weeks after infection. Manifestation of the resistance of ITT (exposed) sheep was suppressed by administration of the immunosuppressant, dexamethasone. Killing of parasites in ITT sheep appeared to have ceased by 21 to 28 days after infection. The basis of the acquired resistance was deemed to be an exceptional immunological capacity of ITT sheep responding to an antigen, or an immunological suppressant, peculiar to F. gigantica. That molecule, produced by juvenile parasites, warrants further study as a candidate for a vaccine.