KINETIC AND CHEMICAL EVIDENCE FOR THE INABILITY OF OXIDIZED ALPHA-1-PROTEINASE INHIBITOR TO PROTECT LUNG ELASTIN FROM ELASTOLYTIC DEGRADATION
KINETIC AND CHEMICAL EVIDENCE FOR THE INABILITY OF OXIDIZED ALPHA-1-PROTEINASE INHIBITOR TO PROTECT LUNG ELASTIN FROM ELASTOLYTIC DEGRADATION
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DOI：
10.1515/bchm2.1984.365.2.731
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
TRAVIS, J
中科院分区：
文献类型：
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作者：
BEATTY, K;MATHESON, N;TRAVIS, J
人α 1-蛋白酶抑制剂的氧化导致该蛋白质转化成不能保护肺弹性蛋白免受弹性蛋白酶降解的形式。显然，这主要是因为修饰的抑制剂和中性粒细胞弹性蛋白酶之间的结合率降低，以及Ki从接近10-14 M变为接近10-10 M。这与香烟烟雾对肺中α 1-蛋白酶抑制剂的氧化导致该器官对弹性蛋白分解降解的保护降低的假设一致。
The oxidation of human .alpha.1-proteinase inhibitor results in the conversion of this protein into a form which cannot protect lung elastin from degradation by elastolytic proteinases. Evidently, this is primarily because of the lowering of the association rate between the modified inhibitor and neutrophil elastase, as well as in a change in Ki from near 10-14 to near 10-10 M. This is consistent with the hypothesis that oxidation of .alpha.1-proteinase inhibitor in the lung by cigarette smoke results in a lowering of the protection of this organ from elastolytic degradation.