Mutation rates among RNA viruses
Mutation rates among RNA viruses
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DOI：
10.1073/pnas.96.24.13910
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发表时间：
1999-11-23
影响因子：
11.1
通讯作者：
Holland, JJ
中科院分区：
文献类型：
--
作者：
Drake, JW;Holland, JJ
自发突变率是模拟种群遗传结构和进化的关键参数。突变累积负荷的影响和增加突变率的后果在评估人群的遗传健康方面很重要。突变频率是更直接可测量的群体参数之一，尽管将它们转换为突变率所需的信息往往很繁琐。以前对RNA病毒(特别是核病毒而不是逆转录病毒)突变率的分析受到可用测量的质量和数量的限制，以及缺乏将突变频率转换为这类生物体的突变率的特定理论框架。在这里，我们描述了核病毒突变频率和突变率之间的简单关系，将其应用于最好的(尽管远不令人满意)可用数据，并观察到每复制一组基因组的突变率的中心值约为0.76。(每轮细胞感染率是该值的两倍，约为1.5。)这个值是如此之大，并且核病毒基因组的信息密度如此之大，以至于即使适度的增加也会导致种群灭绝。
The rate of spontaneous mutation is a key parameter in modeling the genetic structure and evolution of populations. The impact of the accumulated load of mutations and the consequences of increasing the mutation rate are important in assessing the genetic health of populations. Mutation frequencies are among the more directly measurable population parameters, although the information needed to convert them into mutation rates is often racking. A previous analysis of mutation rates in RNA viruses (specifically in riboviruses rather than retroviruses) was constrained by the quality and quantity of available measurements and by the lack of a specific theoretical framework for converting mutation frequencies into mutation rates in this group of organisms. Here, we describe a simple relation between ribovirus mutation frequencies and mutation rates, apply it to the best (albeit far from satisfactory) available data, and observe a central value for the mutation rate per genome per replication of mu(g) approximate to 0.76.(The rate per round of cell infection is twice this value or about 1.5.)This value is so large, and ribovirus genomes are so informationally dense, that even a modest increase extinguishes the population.