Relative responses of aortic body and carotid body chemoreceptors to hypotension.
Relative responses of aortic body and carotid body chemoreceptors to hypotension.
复制标题
主动脉体和颈动脉体化学感受器对低血压的相对反应。
DOI：
--
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
E. Mulligan
中科院分区：
文献类型：
--
作者：
S. Lahiri;T. Nishino;A. Mokashi;E. Mulligan
在 16 只成年猫中测量了在恒定动脉血气和 pH 值下来自主动脉体和颈动脉体的单个或几个化学感受器传入的急性动脉血压变化的反应。在正常碳酸血症和中度缺氧（动脉氧张力为 60 Torr）期间，80 Torr 的诱发低血压会显着增加所有主动脉化学感受器的放电率，但不会增加大多数颈动脉化学感受器的放电率；低血压至 50 托的水平仅轻微刺激大多数颈动脉化学感受器。高氧消除了这种程度的低血压对颈动脉化学感受器的刺激作用；它对主动脉化学感受器的影响程度不同。缺氧对主动脉化学感受器的影响大于对颈动脉化学感受器的影响。因此，低血压的影响取决于动脉氧张力。低血压对主动脉体化学感受器活性的影响越大，表明主动脉体的正常循环限制越大。因此，主动脉化学感受器更适合监测氧气流量的循环变化，颈动脉化学感受器更适合监测呼吸引起的动脉气压变化。
Responses to acute arterial blood pressure changes of a single or a few chemoreceptor afferents from the aortic body and carotid body at constant arterial blood gases and pH were measured in 16 adult cats. During normocapnic normoxia and moderate hypoxia (arterial oxygen tension of 60 Torr) an induced hypotension of 80 Torr increased strikingly the discharge rate of all aortic chemoreceptors but not of most carotid chemoreceptors; hypotension down to the level of 50 Torr stimulated most carotid chemoreceptors only slightly. Hyperoxia eliminated the stimulatory effect of this degree of hypotension on carotid chemoreceptors; it did not affect aortic chemoreceptors to the same extent. Hypoxia augmented the effect on aortic chemoreceptors more than the effect on carotid chemoreceptors. Thus the effect of hypotension was dependent on arterial oxygen tension. The greater effect of hypotension on aortic body chemoreceptor activity indicates a greater normal circulatory constraint for the aortic body. Accordingly, aortic chemoreceptors are more suited to monitor circulatory changes in O2 flow, and carotid chemoreceptors are more suited to monitor arterial gas pressure changes due to respiration.