STRUCTURE OF MALYNGAMIDE-C
STRUCTURE OF MALYNGAMIDE-C
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DOI：
10.1021/jo00216a009
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
MYNDERSE, JS
中科院分区：
文献类型：
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作者：
AINSLIE, RD;BARCHI, JJ;MYNDERSE, JS
Malyngamide C（1）是7（S）-甲氧基十四碳-4（E）-烯酸的含氯酰胺，被发现是来自范宁岛的巨大鞘丝藻亲脂性提取物的主要成分。完整的结构，包括绝对的立体化学，确定通过光谱和化学研究的malyngamide C和几个衍生物。三种结构相关的化合物，即，苹果酸酰胺C乙酸酯（3）、脱氧苹果酸酰胺C（4）和双脱氧苹果酸酰胺C（5）被证明是该化合物的次要成分。
Malyngamide C (1), a chlorine-containing amide of 7(S)-methoxytetradec-4(E)-enoic acid, was found to be a major constituent of the lipophilic extract of Lyngbya majuscula from Fanning Island. The complete structure, including absolute stereochemistry, was determined by spectral and chemical studies of malyngamide C and several derivatives. Three structurally related compounds, viz., malyngamide C acetate (3), deoxymalyngamide C (4), and dideoxymalyngamide C (5), were shown to be minor constituents of the alga.