Evidence for autonomic dysregulation in the irritable bowel syndrome
Evidence for autonomic dysregulation in the irritable bowel syndrome
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DOI：
10.1023/a:1016424007454
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发表时间：
2002-08-01
影响因子：
3.1
通讯作者：
Verne, GN
中科院分区：
文献类型：
--
作者：
Gupta, V;Sheffield, D;Verne, GN
肠易激综合征（IBS）是一种常见的胃肠道疾病，其特征是慢性腹痛和内脏过敏。在这项研究中，记录了20名IBS患者和23名对照者的静息血压和心率。我们评估疼痛强度和不愉快内脏和皮肤刺激使用直肠膨胀和足部浸泡在热水。IBS患者的平均静息心率高于对照组。肠易激综合征患者对内脏和皮肤刺激的疼痛强度和不愉快程度的评分明显高于对照组。在IBS患者中，血压与内脏疼痛呈显著负相关，与皮肤疼痛仅呈微弱正相关；对照组中没有关系。性和焦虑并不能解释这些关系。总之，我们发现了IBS患者中枢自主神经失调的证据。
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and visceral hypersensitivity. In this study, resting blood pressure and heart rate were recorded in 20 IBS patients and 23 controls. We assessed pain intensity and unpleasantness to visceral and cutaneous stimuli using rectal distension and immersion of the foot in hot water. Mean resting heart rate was higher in IBS patients compared to controls. IBS patients rated pain intensity and unpleasantness to visceral and cutaneous stimuli significantly higher than controls. In IBS patients, blood pressure was significantly inversely associated with visceral pain and only weakly and positively associated with cutaneous pain; there were no relationships in controls. Sex and anxiety did not explain these relationships. In conclusion, we found evidence suggestive of central autonomic dysregulation in IBS patients.