Analysis of particle kinematics in spheronization via particle image velocimetry.
Analysis of particle kinematics in spheronization via particle image velocimetry.
复制标题
通过粒子图像测速分析球化过程中的粒子运动学。
DOI：
10.1016/j.ejpb.2012.08.013
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
M. Thommes
中科院分区：
文献类型：
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作者：
Martin Koester;M. Thommes
滚圆是一种广泛应用于药用微丸生产的技术。球化法制得的球团颗粒具有特殊的球形和窄的粒度分布。粒子在球化过程中的运动学目前还不是很清楚。因此，在球化过程中应用粒子图像测速技术(PIV)来可视化粒子的运动和识别流型，以解释各种工艺参数的影响。用高速摄像机记录了常见配方的成球过程，并用粒子图像测速软件对图像进行了处理。采用互相关法确定了球团表面的颗粒速度。系统地改变了配方和工艺参数，考察了它们对颗粒速度的影响。粒子流呈环状，呈扭曲的绳状运动。值得注意的是，总的粒子速度大约比摩擦板的尖端速度低10倍。颗粒速度与球团含水率和造球机负荷有关，而与转速无关。总之，PIV被成功地应用于球化过程，并获得了对粒子速度的新见解。
Spheronization is a wide spread technique in pellet production for many pharmaceutical applications. Pellets produced by spheronization are characterized by a particularly spherical shape and narrow size distribution. The particle kinematic during spheronization is currently not well-understood. Therefore, particle image velocimetry (PIV) was implemented in the spheronization process to visualize the particle movement and to identify flow patterns, in order to explain the influence of various process parameters. The spheronization process of a common formulation was recorded with a high-speed camera, and the images were processed using particle image velocimetry software. A crosscorrelation approach was chosen to determine the particle velocity at the surface of the pellet bulk. Formulation and process parameters were varied systematically, and their influence on the particle velocity was investigated. The particle stream shows a torus-like shape with a twisted rope-like motion. It is remarkable that the overall particle velocity is approximately 10-fold lower than the tip speed of the friction plate. The velocity of the particle stream can be correlated to the water content of the pellets and the load of the spheronizer, while the rotation speed was not relevant. In conclusion, PIV was successfully applied to the spheronization process, and new insights into the particle velocity were obtained.