Photoimmunotherapy for cancer treatment
Photoimmunotherapy for cancer treatment
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DOI：
10.1615/jenvironpatholtoxicoloncol.v25.i1-2.180
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Liu, H
中科院分区：
文献类型：
--
作者：
Chen, WR;Huang, Z;Liu, H
光治疗以其有效的剂量控制和光传递，已成为治疗恶性和非恶性疾病的一种有前途的方式。光化学相互作用，特别是光动力学疗法（PDT）和光热相互作用已经成为癌症治疗中直接细胞破坏的主要机制。临床前研究表明，除了直接的局部细胞毒性，PDT还可以诱导全身免疫反应，这可能会增强对原发性肿瘤和远处转移的治疗效果。选择性光热疗法，使用光吸收染料的原位应用，也被证明是一种有效的局部治疗肿瘤的方法。当与免疫疗法相结合时，光疗的效果可以被放大，可能使光免疫疗法成为一种全身治疗方式。这种光疗-免疫疗法组合，特别是与免疫佐剂结合，已用于临床前研究。这种组合的疗效和长期影响进行了总结，并提出了最近的实验结果。一种新的免疫佐剂，糖化壳聚糖（GC），已被用来加强光化学和光热疗法。PDT-GC联合治疗小鼠乳腺肿瘤和肺肿瘤显著改善了荷瘤动物的长期存活率。GC在染料辅助激光光热疗法中的应用还提供了治疗大鼠转移性肿瘤的长期疗效和抗肿瘤免疫应答。光疗诱导的免疫应答和免疫治疗增强的免疫应答可能成为控制转移性肿瘤的重要机制。
Phototherapy, with its effective dose control and light delivery, has become a promising modality for treating malignant and nonmalignant diseases. Photochemical interaction, specifically photodynamic therapy (PDT), and photothermal interaction have been the primary mechanisms for direct cell destruction in the treatment of cancers. Preclinical studies demonstrate that, in addition to direct local cytotoxicity, PDT can also induce systemic immune responses, which may enhance therapeutic effects on primary tumors and on metastases at distant sites. Selective photothermal therapy, using an in situ application of light-absorbing dye, has also proven to be an effective method for local treatment of tumors. When combined with immunotherapy, the effects of phototherapy can be amplified, potentially making the photoimmunotherapy a systemic treatment modality. This phototherapy-immunotherapy combination, particularly in conjunction with immunoadjuvant, has been used in preclinical studies. The efficacy and long-term effects of such a combination are summarized and the recent experimental results are presented. A new immunoadjuvant, glycated chitosan (GC), has been used to enhance photochemical and photothermal therapies. The PDT-GC combination in the treatment of mammary tumors and lung tumors in mice provided significant improvement in the long-term survival of tumor-bearing animals. The use of GC in dye-assisted laser photothermal therapy also provided long-term curative effects and antitumor immune responses in the treatment of metastatic tumors in rats. The immune responses induced by phototherapy and enhanced by immunotherapy could become important mechanism in the control of metastatic tumors.