Absence of localized grey matter volume changes in the motor cortex following spinal cord injury
Absence of localized grey matter volume changes in the motor cortex following spinal cord injury
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DOI：
10.1016/j.brainres.2004.08.060
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发表时间：
2004-11-26
期刊：
影响因子：
2.9
通讯作者：
Mikulis, DJ
中科院分区：
文献类型：
--
作者：
Crawley, AP;Jurkiewicz, MT;Mikulis, DJ
脊髓损伤 (SCI) 的后果对运动功能有相当大的影响，通常会导致功能障碍。已经研究了创伤部位、脊髓内的头尾部和周围的病理变化。然而，很少有研究调查 SCI 在皮质水平上的后果。磁共振成像 (MRI) 用于探索颈椎 SCI 患者初级运动 (M1) 皮质内灰质和白质的形态变化。 “中央前旋钮”是 M1 皮层专门负责手部功能的标志，被选择用于区域特定的变化测量。将图像分割为灰质、白质和脑脊液 (CSF) 后，使用手动测量对 31 个 SCI 受试者半球和 28 个对照受试者半球进行比较。通过手动方法，在中央前旋钮处测量的灰质面积没有发现显着差异。还进行了基于体素的自动化形态测量分析，结果表明 M1 感兴趣区域内的灰质或白质体积没有显着差异。这些数据表明颈椎 SCI 后 M1 内没有明显的解剖学变化。因此，我们之前报道的 SCI 后皮质运动输出图重组的结果可能是功能组织的变化而不是解剖学的变化。 (C) 2004 Elsevier B.V. 保留所有权利。
The consequences of spinal cord injury (SCI) have considerable effects on motor function, typically resulting in functional impairment. Pathological changes have been studied at the site of trauma, rostrocaudally within the cord, and in the periphery. Few studies, however, have investigated the consequences of SCI at the cortical level. Magnetic resonance imaging (MRI) was used to explore the morphological changes in the grey and white matter within the primary motor (M1) cortex of individuals with cervical SCI. The "precentral knob," a landmark of M1 cortex dedicated to hand function, was selected for regionally specific measurements of change. Thirty-one hemispheres of SCI subjects and 28 hemispheres of control subjects were compared using a manual measurement after the images were segmented into grey matter, white matter, and cerebral spinal fluid (CSF). No significant differences in grey matter area measured at the precentral knob were found with the manual approach. An automated voxel-based morphometric analysis was also performed and demonstrated no significant differences in grey or white matter volume within an M1 region of interest. These data suggest that there is no gross anatomical change within M1 following cervical SCI. Our previously reported findings of reorganization of cortical motor output maps following SCI therefore likely result from changes in functional organization rather than anatomical changes. (C) 2004 Elsevier B.V. All rights reserved.