Coagulopathies and inflammatory diseases: '…glimpse of a Snark'.
Coagulopathies and inflammatory diseases: '…glimpse of a Snark'.
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凝血病和炎症性疾病：“蛇鲨的一瞥”。
DOI：
10.1016/j.coi.2018.09.005
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发表时间：
2018
影响因子：
7
通讯作者：
Rothlin,CarlaV
中科院分区：
文献类型：
--
作者：
DelCarmen,Silvina;Hapak,SophieM;Ghosh,Sourav;Rothlin,CarlaV
凝血级联反应的分子直接调节炎症和抗病原体防御。多种炎症性疾病显示出与凝血病的有趣联系。编码抗凝剂的基因中的功能丧失突变可能被保留以改善宿主防御。凝血病和炎症性疾病表面上有不同的潜在分子基础。尽管如此，两者都是宿主对身体伤害的防御机制。在无脊椎动物中，凝血可以直接在抗病原体防御中发挥作用。脊椎动物凝血级联反应的分子也与炎症的调节直接相关。我们认为，血栓形成倾向可能提供抵抗脊椎动物病原体。提高抗病原体防御的选择压力可能保留了与人群中的血栓形成状态相关的突变，并直接导致炎症增强。事实上，在一些炎性疾病中，至少一部分患者可以被鉴定为高凝状态。因此，抗凝剂如华法林或阿哌沙班可能对某些炎症性疾病具有治疗作用。
HighlightsMolecules of the coagulation cascade directly regulate inflammation and anti-pathogen defense.Multiple inflammatory disorders show an intriguing association with coagulopathies.Loss-of-function mutations in genes encoding anticoagulants might have been retained for improved host defense.Coagulopathies and inflammatory diseases, ostensibly, have distinct underlying molecular bases. Notwithstanding, both are host defense mechanisms to physical injury. In invertebrates, clotting can function directly in anti-pathogen defense. Molecules of the vertebrate clotting cascade have also been directly linked to the regulation of inflammation. We posit that thrombophilia may provide resistance against pathogens in vertebrates. The selective pressure of improved anti-pathogen defense may have retained mutations associated with a thrombophilic state in the human population and directly contributed to enhanced inflammation. Indeed, in some inflammatory diseases, at least a subset of patients can be identified as hypercoagulable. Therefore, anticoagulants such as warfarin or apixaban may have a therapeutic role in some inflammatory diseases.