Risk for depression is associated with neural biases in emotional categorisation
Risk for depression is associated with neural biases in emotional categorisation
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DOI：
10.1016/j.neuropsychologia.2008.05.030
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发表时间：
2008-10-01
期刊：
影响因子：
2.6
通讯作者：
Norbury, Ray
中科院分区：
文献类型：
--
作者：
Chan, Stella W. Y.;Harmer, Catherine J.;Norbury, Ray
情绪处理中的负性偏见是抑郁症的一个主要特征。最近的研究表明，即使在没有抑郁症病史的高危人群中，这种负面偏见也很明显，这表明它们可能是抑郁症的关键脆弱性标志。然而，这些行为观察的神经基础尚未得到充分探索。因此，本研究旨在(1)阐明情绪性人格特质词汇分类的神经过程；(2)研究这些神经机制是否在高风险个体中偏向于负面信息。抑郁风险定义为高神经质(N)。我们招募了一个高风险（高N）和低菲斯克（低N）从未抑郁的年轻人样本。在对正面和负面自我指涉人格特质词汇（如诚实、粗鲁）进行分类和记忆时获得功能磁共振成像（fMRI）。高风险志愿者在右侧顶叶上皮层比低风险志愿者表现出更大的反应，特别是在对消极词汇进行分类时。此外，在消极词汇分类时，神经质得分与左前扣带神经反应呈正相关，而在消极词汇检索时，同一区域内神经反应呈负相关。这些结果强调了额顶叶回路在情绪处理中的作用，并进一步表明这些神经过程中的负面偏见可能与抑郁风险有关。(C) 2008 Elsevier Ltd版权所有。
Negative biases in emotional processing are a major characteristic of depression. Recent research has shown that Such negative biases are evident in high risk individuals even in the absence of personal history of depression, suggesting that they may serve as key vulnerability markers of depression. However, the neural basis of these behavioural observations has not been fully explored. This study therefore aimed to (I) illustrate the neural processes involved in the categorisation of emotional personality-trait words; and (2) examine whether these neural mechanisms are biased towards negative information in high risk individuals. Risk for depression was defined by high neuroticism (N). We recruited a sample of high risk (high N) and low Fisk (low N) never-depressed young adults. Functional magnetic resonance imaging (fMRI) was acquired during the categorisation and memory for positive and negative self-referent personality-trait Words (e.g. honest, rude). High risk volunteers showed greater responses in the right superior parietal cortex than low risk Volunteers specifically during the categorisation of negative words. Moreover, neuroticism score was positively correlated with neural responses in the left anterior cingulate during the categorisation of negative words but negatively correlated within the same region during the retrieval of these words. These results highlight a role of the fronto-parietal circuitry in emotional processing and further Suggest that negative biases in these neural processes may be involved in risk for depression. (C) 2008 Elsevier Ltd. All rights reserved.