Systemic immunity against a murine colon tumor (CT‐26) produced by immunization with syngeneic cells expressing a transfected viral gene product
Systemic immunity against a murine colon tumor (CT‐26) produced by immunization with syngeneic cells expressing a transfected viral gene product
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通过表达转染病毒基因产物的同基因细胞免疫产生针对小鼠结肠肿瘤（CT-26）的全身免疫力
DOI：
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发表时间：
1989
影响因子：
6.4
通讯作者：
P. Frost
中科院分区：
文献类型：
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作者：
H. Schackert;T. Itaya;G. Schackert;E. Fearon;B. Vogelstein;P. Frost
我们之前已经证明，表达流感病毒的转染血凝抗原的CT-26肿瘤细胞在同基因宿主中引发免疫应答，该免疫应答对皮下注射流感病毒具有交叉保护作用。用未转染的亲本细胞进行攻击。由于CT-26是一种鼠结直肠癌，我们试图确定在将亲本肿瘤细胞注射到结肠肿瘤生长和转移的常见部位后是否可以实现相同的免疫保护作用。我们现在表明，这种免疫方案提供的保护是全身性的，动物可以免受盲肠、肠系膜、肝脏和肺部肿瘤生长的影响。
We have previously shown that CT‐26 tumor cells expressing the transfected hemagglutination antigen of influenza virus elicit an immune response in syngeneic hosts that is cross‐protective against an s.c. challenge with non‐transfected parental cells. Since CT‐26 is a murine colorectal carcinoma we sought to determine whether the same immuno‐protective effect could be achieved after a challenge with parent tumor cells injected into the usual sites of colon tumor growth and metastasis. We now show that the protection afforded by this immunization protocol is systemic and that animals can be protected against tumor growth in the cecum, lymphatics of the mesentery, liver and lung.
通过转染外源基因在小鼠肿瘤中诱导免疫原性肿瘤变体。
影响因子：
11.2
作者：
Fearon,ER;Itaya,T;Hunt,B;Vogelstein,B;Frost,P
通讯作者：
Frost,P