Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus
Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus
复制标题
DOI：
10.1016/s0196-9781(99)00021-2
复制
发表时间：
1999-01-01
期刊：
影响因子：
3
通讯作者：
Dores, RM
中科院分区：
文献类型：
--
作者：
Alrubaian, J;Danielson, P;Dores, RM
最近对鲟鱼脑垂体的研究，导致克隆了编码激素原，阿黑皮素原（POMC）的cDNA。该cDNA被命名为鲟鱼POMC A。随后对鲟鱼脑垂体的分析发现了第二个不同的POMC cDNA（鲟鱼POMC B）。在两种鲟鱼POMC cDNA中，开放阅读框的长度为795个核苷酸。然而，两种鲟鱼POMC cDNA在开放框架中的26个氨基酸位置处不同。此外，两种形式的POMC在开放阅读框内的45个核苷酸位置处不同。比较了两种鲟鱼POMC基因cDNA点突变的数量和类型，并对两种POMC基因的起源进行了讨论。(C)1999 Elsevier Science Inc. All rights reserved.
A recent study on the pituitary of the sturgeon, Acipenser transmontanus, resulted in the cloning of a cDNA that codes for the prohormone, proopiomelanocortin (POMC). This cDNA is designated sturgeon POMC A. Subsequent analysis of the sturgeon pituitary uncovered a second distinct POMC cDNA (sturgeon POMC B). In both sturgeon POMC cDNAs the open reading frame is 795 nucleotides in length. However, the two sturgeon POMC cDNAs differ at 26 amino acid positions in the opening frame. In addition, the 2 forms of POMC differ at 45 nucleotide positions within the open reading frame. The number and types of point mutations are compared in the 2 sturgeons POMC cDNAs, and the origin of the two POMC genes is discussed. (C) 1999 Elsevier Science Inc. All rights reserved.