IPSPs modulate spike backpropagation and associated [Ca2+](i) changes in the dendrites of hippocampal CA1 pyramidal neurons
IPSPs modulate spike backpropagation and associated [Ca2+](i) changes in the dendrites of hippocampal CA1 pyramidal neurons
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DOI：
10.1152/jn.1996.76.5.2896
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发表时间：
1996-11-01
影响因子：
2.5
通讯作者：
Ross, WN
中科院分区：
文献类型：
--
作者：
Tsubokawa, H;Ross, WN
1.我们研究了突触抑制对大鼠海马CA1区锥体神经元顶树突反向传播Na+峰的影响。刺激辐射层可诱发突触性动作电位，刺激肺泡可诱发逆向性动作电位。2.抑制性突触后电位，引起的刺激层陷窝moleculare，减少了单个尖峰的幅度在远端树突，但没有改变的幅度在躯体或近端区域。抑制也减少了尖峰相关的[Ca 2 +]（i）的变化在远端树突，但几乎没有影响的变化在近端部分的细胞。这两个结果都与抑制作用将主动反向传播的尖峰转换为树枝上某个点的被动扩散电位相一致。在大多数细胞中，远端树突的峰电位幅度降低被甲碘荷包牡丹碱（10 μ M）阻断，并且当在一个时间窗内诱发时，抑制作用最有效
1. We studied the effects of synaptic Inhibition on backpropagating Na+ spikes in the apical dendrites of CA1 pyramidal neurons in transverse slices from the rat hippocampus. Action potentials were evoked synaptically by stimulation in the stratum radiatum or antidromically by stimulation in the alveus. 2. Inhibitory postsynaptic potentials, evoked by stimulation in the stratum lacunosum moleculare, reduced the amplitude of single spikes in the distal dendrites but did not change the amplitudes in the somatic or proximal regions. Inhibition also reduced the spike-associated [Ca2+](i) changes in the distal dendrites but had little effect on the changes in the proximal part of the cell. Both of these results are consistent with inhibition converting actively backpropagating spikes into passively spreading potentials at some point in the arbor.3. In most cells, the spike amplitude reduction in the distal dendrites was blocked by bicuculline methiodide (10 mu M) and inhibition was most effective when evoked in a time window