Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes
Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes
复制标题
使用羧基多壁碳纳米管的改性玻碳电极伏安法测定磺酰胺
DOI：
10.5935/0103-5053.20160114
复制
发表时间：
2016-12-01
影响因子：
1.4
通讯作者：
Chen, Wen-bo
中科院分区：
文献类型：
--
作者：
He, Bao-shan;Chen, Wen-bo
以N，N-二甲基甲酰胺（DMF）为介质，制备了羧基多壁碳纳米管（MWCNTs）修饰并经超声分散的新型玻碳电极（DMF/carboxyl/MWCNTs/GCE），用于磺胺类药物的电化学测定。采用循环伏安法和交流阻抗法研究了基于DMF/羧基/MWCNTs/GCE的SA的电化学行为。优化了缓冲液pH值、扫描速率、修饰量等实验参数对电极响应的影响。在最佳条件下，该传感器对磺胺类药物的线性响应范围为5.0 × 10-7 ~ 1.1 × 10-4 mol L-1（R = 0.999），磺胺二甲嘧啶（R = 0.990），磺胺嘧啶（R = 0.997），磺胺甲恶唑（R = 0.996），检出限分别为1.65 × 10-8，3.19 × 10-8，6.76 × 10-8和9.41 × 10-8 molL-1。回收率在约100%范围内。相对标准偏差（RSD）<5%。该传感器通过循环伏安法测试，重复性和稳定性超过90%的原始活动。该方法为进一步研究磺胺类化合物的复杂结构提供了可行性和适用性。
New glassy carbon electrode (GCE) modified with carboxyl multiwalled carbon nanotubes (MWCNTs) and treated with ultrasonic dispersing in N,N-dimethylfomamide (DMF) media, namely DMF/carboxyl/MWCNTs/GCE, was prepared for electrochemical determination of sulfonamides (SAs). Electrochemical behavior of SAs based on DMF/carboxyl/MWCNTs/GCE was investigated by cyclic voltammetry and impedance spectroscopy. The effects of various experimental parameters on the response of electrode such as pH of buffer, scan rate and the amount of modification were optimized. Under the optimal conditions, the obtained sensor presented linear response to SAs in the range of 5.0 × 10-7 to 1.1 × 10-4 mol L-1 of sulfonamide (R = 0.999), sulfamethazine (R = 0.990), sulfadiazine (R = 0.997), sulfamethoxazole (R = 0.996) and the limits of detection of 1.65 × 10-8, 3.19 × 10-8, 6.76 × 10-8 and 9.41 × 10-8 mol L-1, respectively. The recoveries were in the range of ca. 85-103% with relative standard deviation (RSD) < 5%. The sensor was tested by cyclic voltammetry with repeatability and stability of more than 90% of its original activity. The proposed method might offer feasibility and applicability of the sensor for further complex sulfonamides compounds.