Recent advances in the biology of human circulating tumour cells and metastasis.
Recent advances in the biology of human circulating tumour cells and metastasis.
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DOI：
10.1136/esmoopen-2016-000078
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发表时间：
2016
期刊：
影响因子：
7.3
通讯作者：
Aceto N
中科院分区：
文献类型：
--
作者：
Gkountela S;Szczerba B;Donato C;Aceto N
转移性疾病的发展被认为是90%以上被诊断为癌症的患者的死亡原因。长期以来，由于研究患者中广泛存在的癌症病变的困难，以及在疾病进展过程中缺乏可靠的方法来分离存活的转移细胞，对转移的生物学特征的了解一直受到阻碍。这些困难对我们开发专为阻止癌症扩散而量身定做的新制剂的能力产生了负面影响。然而，最近在分离循环肿瘤细胞(CTCs)的专门设备方面的进展，以及能够对其基因组和转录组进行单细胞分辨询问的技术，现在正在为理解驱动转移形成的分子机制铺平道路。在这篇综述中，我们旨在总结几种癌症背景下在CTC生物学方面的一些最新发现，并强调那些有可能改善转移性癌症患者临床治疗的发现。
The development of a metastatic disease is recognised as the cause of death of over 90% of patients diagnosed with cancer. Understanding the biological features of metastasis has been hampered for a long time by the difficulties to study widespread cancerous lesions in patients, and by the absence of reliable methods to isolate viable metastatic cells during disease progression. These difficulties negatively impact on our ability to develop new agents that are tailored to block the spread of cancer. Yet, recent advances in specialised devices for the isolation of circulating tumour cells (CTCs), hand-in-hand with technologies that enable single cell resolution interrogation of their genome and transcriptome, are now paving the way to understanding those molecular mechanisms that drive the formation of metastasis. In this review, we aim to summarise some of the latest discoveries in CTC biology in the context of several types of cancer, and to highlight those findings that have a potential to improve the clinical management of patients with metastatic cancer.