STUDIES ON EXTRACELLULAR-MATRIX COMPONENTS THAT PROMOTE NEURITE OUTGROWTH
STUDIES ON EXTRACELLULAR-MATRIX COMPONENTS THAT PROMOTE NEURITE OUTGROWTH
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DOI：
10.1101/sqb.1983.048.01.065
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
REICHARDT, LF
中科院分区：
文献类型：
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作者：
LANDER, AD;TOMASELLI, K;REICHARDT, LF
多细胞生物体发育的一个重要决定因素是细胞附着、迁移和分化的细胞外基质（ECM）。很可能会发现一类影响神经元发育的物质与ECM相关。在神经元发育的早期阶段，在纤维连接蛋白的出现和颗粒细胞迁移以形成小脑中的外部颗粒细胞层（哈滕et al. 1982）以及神经嵴细胞迁移以形成源自嵴的各种组织（Thiery et al. 1982）之间观察到强烈的空间和时间相关性。当小脑颗粒细胞或神经嵴细胞在体外培养时，它们在纤连蛋白基质上粘附和迁移的能力与它们在体内的迁移行为在时间上相关（哈滕et al. 1982; Rovasio et al. 1983）。ECM在神经元发育的后期也很重要。生长锥与其基质之间的相互作用可以决定其生长速度和体外生长路径（Letourneau 1975）。在体内，轴突也可以遵循由基质决定的路线（Katz和Lasek 1979）。在某些情况下，这反映了轴突与已经定向的细胞的关联，例如小脑中的放射状神经胶质（Rakic 1974）和水蚤中的先驱纤维（Levinthal et al. 1976）。
An important determinant in the development of multicellular organisms is the extracellular matrix (ECM) upon which cells attach, migrate, and differentiate. It is likely that a class of substances that affect neuronal development will be found to be associated with the ECM. During early stages of neuronal development, strong spatial and temporal correlations are seen between the appearance of fibronectin and migration of granule cells to form the external granule cell layer in the cerebellum (Hatten et al. 1982) and migration of neural crest cells to form the variety of tissues derived from the crest (Thiery et al. 1982). When cerebellar granule cells or neural crest cells are cultured in vitro, their abilities to adhere to and migrate on fibronectin substrata correlate temporally with their migratory behaviors in vivo (Hatten et al. 1982; Rovasio et al. 1983).The ECM is also important in later stages of neuronal development. The interaction between a growth cone and its substratum can determine the rate at which it grows and the paths it follows in vitro (Letourneau 1975). In vivo, axons may also follow routes determined by the substratum (Katz and Lasek 1979). In some cases, this reflects the association of axons with already oriented cells, eg, radial glia in the cerebellum (Rakic 1974) and pioneer fibers in Daphnia (Levinthal et al. 1976).