HPV-associated flat penile lesions in men of a non-STD hospital population: Less frequent and smaller in size than in male sexual partners of women with CIN
HPV-associated flat penile lesions in men of a non-STD hospital population: Less frequent and smaller in size than in male sexual partners of women with CIN
复制标题
DOI：
10.1002/ijc.20502
复制
发表时间：
2005-01-01
影响因子：
6.4
通讯作者：
Meijer, CJLM
中科院分区：
文献类型：
--
作者：
Bleeker, MCG;Hogewoning, CJA;Meijer, CJLM
人乳头瘤病毒（HPV）感染和HPV相关的阴茎病变是常见的女性宫颈上皮内瘤变（CIN）的男性性伴侣。为了确定这些发现的意义，我们研究了HPV和HPV相关的阴茎病变在男性医院人群与非性病投诉的患病率。应用醋酸后进行阴茎镜检查，以确定扁平病变，丘疹病变，尖锐湿疣和珍珠阴茎丘疹（PPPs）。用GP 5 +6+ PCR检测阴茎刮片中HPV DNA的存在。在HPV 16阳性的情况下，使用基于LightCycler的实时PCR方法定量病毒载量。将非STD男性住院人群（n = 118）与CIN女性的男性性伴侣（n = 238）进行比较，分别在14%和60%的男性中发现扁平阴茎病变，在25%和59%的男性中发现阴茎HPV。我们发现，阴茎HPV的存在，以及在HPV 16阳性的情况下，较高的病毒载量与阴茎扁平病变的存在相关。在HPV阳性男性中，CIN女性的男性性伴侣的扁平阴茎病变比非STD医院人群更常见且尺寸更大。HPV感染和HPV相关的扁平阴茎病变常见于非STD男性人群。然而，这些病变的出现频率较低，尺寸小于CIN女性的男性性伴侣。CIN女性男性性伴侣阴茎刮片中较高的病毒载量反映为扁平阴茎病变的患病率较高且这些病变的尺寸较大。(C)2004威利-利斯公司
Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population with non-STD complaints. Penoscopy was performed after application of acetic acid to identify flat lesions, papular lesions, condylomata acuminata and pearly penile papules (PPPs). Presence of HPV DNA in penile scrapes was tested by GP5+6+ PCR. In case of HPV 16 positivity, viral loads were quantified using a LightCycler based real-time PCR method. Comparing the non-STD male hospital population (n = 118) with the male sexual partners of women with CIN (n = 238), flat penile lesions were found in 14% vs. 60% and penile HPV in 25% vs. 59% of the men, respectively. We found that the presence of penile HPV and, in case of HPV 16 positivity, higher viral loads were associated with the presence of flat penile lesions. Amongst the HPV-positive men, flat penile lesions were more common and larger in size in male sexual partners of women with CIN than in the non-STD hospital population. HPV infections and HPV-associated flat penile lesions are commonly found in the non-STD male population. However, these lesions are less frequently present and smaller in size than in male sexual partners of women with CIN. Higher viral loads in penile scrapes of male sexual partners of women with CIN are reflected by a higher prevalence of flat penile lesions and a larger size of these lesions. (C) 2004 Wiley-Liss, Inc.