Extracellular matrix: A matter of life and death
Extracellular matrix: A matter of life and death
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DOI：
10.1080/03008200802143190
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Mongiat, Maurizio
中科院分区：
文献类型：
--
作者：
Marastoni, Stefano;Ligresti, G.;Mongiat, Maurizio
从结构和功能的角度来看，细胞外基质（ECM）是基质微环境的重要组成部分。ECM作为组织组织的支架发挥作用，并调节生长因子和趋化因子的可用性，从而有助于维持组织稳态。细胞与ECM的附着对于支持细胞生存、生长和增殖至关重要，缺乏这些相互作用可能会引发一种称为失巢凋亡的细胞死亡。一些研究指出，ECM组成的改变通常是许多病理条件如癌症的原因，它已被证明偶尔是主要的启动子。ECM并不总是代表促生存刺激;在ECM分子的不同阵列中，一组蛋白质可以对细胞活力产生负面影响，并被认为在肿瘤进展中发挥重要作用。由于这个原因，注意力集中在这些分子作为潜在的工具或治疗的目标。
Extracellular matrix (ECM) is an essential component of the stromal microenvironment both from a structural and a functional point of view. The ECM functions as a scaffold for tissue organization and regulates growth factors and chemokines availability thus contributing to maintain tissue homeostasis. Attachment of cells to ECM is essential to support cell survival, growth, and proliferation, and the lack of these interactions can trigger a type of cell death named anoikis. Several studies point out that alterations of ECM composition are often responsible of many pathological conditions such as cancer, of which it has been demonstrated to be occasionally the main promoter. ECM does not always represent a prosurvival stimulus; among the different array of ECM molecules a set of proteins can negatively affect cell viability and are thought to play an important role in tumor progression. For this reason attention has been focused on these molecules as potential tools or targets for therapy.