PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases.
PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases.
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DOI：
10.1042/cs20130463
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Ma JX
中科院分区：
文献类型：
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作者：
He X;Cheng R;Benyajati S;Ma JX
色素上皮衍生因子(PEDF)是丝氨酸蛋白酶抑制因子(Serpin)家族中广泛表达的多功能成员。这种被广泛研究的蛋白质在许多生理和病理生理过程中发挥着关键作用，包括神经保护、血管生成、纤维化和炎症。本文综述了PEDF在不同发育和成体器官中的时空分布模式，并讨论了其在维持生理内稳态中的作用。本综述的重点是讨论PEDF在糖尿病和缺氧诱导的血管生成中的意义，以及在这些条件下PEDF的作用途径。此外，还对PEDF的表达、功能和降解的调控机制进行了综述。最后，简要总结了PEDF作为一种抗血管生成药物的治疗潜力。
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes, including neuroprotection, angiogenesis, fibrogenesis and inflammation. The present review summarizes the temporal and spatial distribution patterns of PEDF in a variety of developing and adult organs, and discusses its functions in maintaining physiological homoeostasis. The major focus of the present review is to discuss the implication of PEDF in diabetic and hypoxia-induced angiogenesis, and the pathways mediating PEDF's effects under these conditions. Furthermore, the regulatory mechanisms of PEDF expression, function and degradation are also reviewed. Finally, the therapeutic potential of PEDF as an anti-angiogenic drug is briefly summarized.