Development and Calibration of Biochemical Models for Testing Dental Restorations.
Development and Calibration of Biochemical Models for Testing Dental Restorations.
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DOI：
10.1016/j.actbio.2020.04.014
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发表时间：
2020-04
影响因子：
9.7
通讯作者：
Anqi Zhang;Ruoqiong Chen;W. Aregawi;Yiting He;Sheng Wang;C. Aparicio;J. Rudney;H. P. Chew;A. Fok
中科院分区：
文献类型：
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作者：
Anqi Zhang;Ruoqiong Chen;W. Aregawi;Yiting He;Sheng Wang;C. Aparicio;J. Rudney;H. P. Chew;A. Fok
树脂基复合材料是目前临床上最常用的牙体修复材料。虽然这些材料的性能已经得到了显着改善，以及更好的临床技术用于他们的位置，早期修复失败仍然发生得太频繁。由于临床研究需要数年才能完成，并且新的树脂复合材料的生产速度越来越快，因此有必要使用加速但具有代表性的测试进行实验室评估。树脂复合材料修复的主要失败类型是牙齿/修复体断裂和继发性龋，这是由机械和生物化学挑战的组合引起的。在这项研究中，生物膜模型（S。mutans）和用于在牛牙本质中产生人工龋的化学模型（乳酸缓冲液），并针对原位数据进行校准。使用脱矿深度和挑战持续时间之间的幂律关系，确定每个模型不同pH值下将体外持续时间转换为等效临床持续时间的比例因子。的比例因子将允许同步的生化和机械的挑战，在他们的行动率，以潜在的测试树脂复合材料修复在加速，但临床上有代表性的martens.Statement的重要性虽然树脂复合材料的性能牙科修复已得到显着改善，早期修复失败仍然发生得太频繁。由于临床研究需要数年才能完成，因此需要进行加速实验室测试。树脂复合修复体的失败主要是由于断裂和继发龋，这是由机械和生物化学挑战的组合引起的。在这项研究中，生物膜和化学模型，用于生产人工龋在牛牙本质的校准对原位数据。使用脱矿深度和挑战持续时间之间的幂律关系，确定每个模型的不同pH值的比例因子。比例因子将允许以加速但具有临床代表性的方式同步测试树脂复合材料修复体中的生物化学和机械挑战。
Currently, resin composites are the most popular materials for dental restoration in clinical practice. Although the properties of such materials have been improved significantly, together with better clinical techniques used for their placement, early restoration failure still occurs too frequently. As clinical studies take years to complete, and new resin composites are being produced at ever increasing pace, laboratory assessment using accelerated but representative tests is necessary. The main types of failure in resin-composite restoration are tooth/restoration fracture and secondary caries, which are caused by a combination of mechanical and biochemical challenges. In this study, a biofilm model (S. mutans) and a chemical model (lactic-acid buffer) for producing artificial caries in bovine dentin are developed and calibrated against in situ data. Using a power law relationship between the demineralization depth and challenge duration, scale factors that convert the in vitro durations to the equivalent clinical durations are determined for different pH values for each model. The scale factors will allow the synchronization of biochemical and mechanical challenges in terms of their rates of action to potentially test resin-composite restoration in an accelerated but clinically representative manner.Statement of significanceAlthough the properties of resin composites for dental restoration have been improved significantly, early restoration failure still occurs too frequently. As clinical studies take years to complete, accelerated laboratory testing is necessary. Resin-composite restoration fail mainly through fracture and secondary caries, caused by a combination of mechanical and biochemical challenges. In this study, a biofilm and a chemical model for producing artificial caries in bovine dentin are calibrated against in situ data. Using a power law relationship between demineralization depth and challenge duration, scale factors are determined for different pH for each model. The scale factors will allow the synchronization of biochemical and mechanical challenges in testing resin-composite restoration in an accelerated but clinically representative manner.