A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy
A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy
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DOI：
10.1016/s0165-0378(01)00119-x
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发表时间：
2002-01-01
影响因子：
3.4
通讯作者：
Martal, J
中科院分区：
文献类型：
--
作者：
Chaouat, G;Zourbas, S;Martal, J
将注意力集中在母胎界面的细胞因子上是该领域取得的主要进展之一。这在很大程度上要归功于汤姆·韦格曼的远见卓识，以及免疫营养主义和Th1/Th2模式在该领域带来的变化。然而，一些新发现的细胞因子并不符合经典的Th1/Th2二分法。然而，由于它们激活或下调NK细胞的能力，通过它们对黏附分子的作用，以及它们对血管形成过程的调节作用，它们可能在母胎关系中引起了兴趣。因此，我们首先对IL-11、IL-12、IL-13、IL-15、IL-16、IL-17和IL-18在子宫、围着床期胚胎以及随后在整个妊娠过程中在蜕膜和胎盘组织中的表达进行了系统的研究。这些细胞因子在每一种情况下都被检测到，每一种情况下都有精确的定位，这将是详细的，这确实表明了重要的调节功能，特别是在植入期间。在某些情况下，正如将在围着床期子宫中显示的那样，这些细胞由子宫GMG-NK样细胞完美地表达，已经或正在进行比较ELISA和定量RT-PCR，但是已经观察到的表达模式，以及对于一些GMG NK样细胞的非常精确的出现窗口以及各自分布的复杂性，强烈地表明，尽管在一段时间内它肯定是有用的，但现在必须认为Th1/Th2范式必须被认为是过于简单化。相反，现有的数据指向连续的窗口，并暗示着一个极端复杂的系统与非常精确的定时和调整相关联。他们还表明，母胎关系不仅仅是母体对外来组织的耐受性，而是一系列复杂的相互细胞因子相互作用，控制着选择性免疫调节，以及在对话期间对黏附和血管形成过程的控制。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Focussing attention on cytokines at the materno-foetal interface represents one of the major advances made in the field. This owes much to the visionary views of Tom Wegmann, and to the changes brought about in the field by immunotrophism and Th1/Th2 paradigms. We review these briefly and also point out some emerging problems.However, a certain number of newly discovered cytokines do not fit into the classical Th1/Th2 dichotomy. Yet, by their capacity to activate or downregulate NK cells, by their action on adhesion molecules, and by their regulatory effects on the vascularisation process, they are of possible interest within the materno-foetal relationship. Therefore, as a first step, we have undertaken a systematic study of the expression of IL-11, IL-12, IL-13, IL-15, IL-16, IL-17 and IL-18 in the uterus, the peri-implantation embryo, and later on decidual and placental tissues throughout pregnancy. These cytokines were detected in every case, with, in each case, a precise localisation, which will be detailed, and which indeed suggests important regulatory functions, especially during implantation. In some cases, as will be shown in the peri-implantation uterus, those cells are perfectly expressed by uterine GMG-NK-like cells, Comparative ELISAs and quantitative RT-PCR have been or are being conducted, but already the expression patterns that are observed, and the very precise window of appearance that is observed for some of the GMG NK-like cells, either around or in the implanting embryo, as well as the complexity of the respective distributions, strongly suggest that, as useful as it certainly was for a while, the Th1/Th2 paradigm must now be considered as an over-simplification. Rather, the existing data point to sequential windows and are suggestive of a system where an extreme complexity is allied to very precise timing and tuning. They also suggest that the materno-foetal relationship is not simply maternal tolerance of a foreign tissue, but a series of intricate mutual cytokine interactions governing selective immune regulation and also control of the adhesion and vascularisation processes during this dialogue. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.