microRNAs in mycobacterial disease: friend or foe?
microRNAs in mycobacterial disease: friend or foe?
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DOI：
10.3389/fgene.2014.00231
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发表时间：
2014
影响因子：
3.7
通讯作者：
Liu PT
中科院分区：
文献类型：
--
作者：
Mehta MD;Liu PT
As the role of microRNA in all aspects of biology continues to be unraveled, the interplay between microRNAs and human disease is becoming clearer. It should come of no surprise that microRNAs play a major part in the outcome of infectious diseases, since early work has implicated microRNAs as regulators of the immune response. Here, we provide a review on how microRNAs influence the course of mycobacterial infections, which cause two of humanity’s most ancient infectious diseases: tuberculosis and leprosy. Evidence derived from profiling and functional experiments suggests that regulation of specific microRNAs during infection can either enhance the immune response or facilitate pathogen immune evasion. Now, it remains to be seen if the manipulation of host cell microRNA profiles can be an opportunity for therapeutic intervention for these difficult-to-treat diseases.
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DOI：
10.4049/jimmunol.0803560
发表时间：
2009-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lu TX;Munitz A;Rothenberg ME
通讯作者：
Rothenberg ME
影响因子：
30.3
作者：
Montoya D;Cruz D;Teles RM;Lee DJ;Ochoa MT;Krutzik SR;Chun R;Schenk M;Zhang X;Ferguson BG;Burdick AE;Sarno EN;Rea TH;Hewison M;Adams JS;Cheng G;Modlin RL
通讯作者：
Modlin RL
影响因子：
6.7
作者：
Chatterjee S;Dwivedi VP;Singh Y;Siddiqui I;Sharma P;Van Kaer L;Chattopadhyay D;Das G
通讯作者：
Das G
影响因子：
4.8
作者：
Bala, Shashi;Marcos, Miguel;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
56.9
作者：
Liu, PT;Stenger, S;Modlin, RL
通讯作者：
Modlin, RL