Two new benzophenones from Dobinea delavayi
Two new benzophenones from Dobinea delavayi
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DOI：
10.1016/j.phytol.2021.10.017
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发表时间：
2021-12
影响因子：
1.7
通讯作者：
Yi Shen;Hao Chen;Li Lang;Xiang Dong;Chao-Jiang Xiao;B. Jiang
中科院分区：
文献类型：
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作者：
Yi Shen;Hao Chen;Li Lang;Xiang Dong;Chao-Jiang Xiao;B. Jiang
Two new benzophenones, 2,6,3′,4′-tetrahydroxy-4-methoxybenzophenone (1) and 2,6,4′-trihydroxy-4,3′-dimethoxybenzophenone (2), together with four known phenolic compounds (3-6) were isolated from the roots ofDobinea delavayi(Anacardiaceae). Structures of the isolated compounds were determined by the comprehensive analyses of the physicochemical properties and spectral data (NMR and MS).In vitroantimalarial activity and cytotoxicity of isolated compounds were evaluated byβ-hematin formation inhibition assay and MTT colorimetric assay, respectively. Compound6exhibited significantin vitroantimalarial activity with IC50value of 42.1 μg/mL. Compound4exhibited weak cytotoxicity against HepG2 and MCF-7 cells with IC50values of 169.2 and 192.0 μg/mL.
