Utility of Waist-To-Height Ratio in Detecting Central Obesity and Related Adverse Cardiovascular Risk Profile Among Normal Weight Younger Adults (from the Bogalusa Heart Study)
Utility of Waist-To-Height Ratio in Detecting Central Obesity and Related Adverse Cardiovascular Risk Profile Among Normal Weight Younger Adults (from the Bogalusa Heart Study)
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DOI：
10.1016/j.amjcard.2009.04.037
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发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Berenson, Gerald S.
中科院分区：
文献类型：
--
作者：
Srinivasan, Sathanur R.;Wang, Ren;Berenson, Gerald S.
在正常体重的年轻人中，关于腰高比在检测中心性肥胖和相关心血管风险方面的效用的数据很少。对639名正常体重（体重指数18.5 - 24.9 kg/m2）的20 - 44岁黑人和白色成人（75%白色和36%男性）进行了这方面的检查。腰高比>= 0.5的受试者被分组为中心性肥胖正常体重，其余被视为对照组。在调整年龄、种族和性别后，与对照组相比，中心性肥胖受试者的舒张压、平均动脉压、低密度脂蛋白胆固醇水平、甘油三酯、甘油三酯/高密度脂蛋白胆固醇比值、胰岛素、胰岛素抵抗的稳态模型评估、尿酸、C反应蛋白、和肝功能酶（丙氨酸氨基转移酶和T-谷氨酰转移酶）。在多变量分析中，中心性肥胖组与对照组相比，平均动脉压、甘油三酯/高密度脂蛋白胆固醇比值、胰岛素抵抗的稳态模型评估和C反应蛋白的显著不良水平（最高三分位数vs其余）分别高出1.9、2.2、2.9和2.5倍。中心性肥胖组血脂异常、高血压、胰岛素抵抗、高尿酸血症和C反应蛋白升高的患病率也更高。与对照组相比，中心性肥胖组的颈总动脉内膜中层厚度（亚临床动脉粥样硬化的测量）的年龄、种族和性别校正平均值更大（0.76 vs 0.71 mm，p = 0.009）。总之，这些发现强调了腰高比在检测正常体重年轻人中的中心性肥胖和相关不良心血管风险方面的实用性。(C)2009年由Elsevier Inc.出版(Am J Cardiol 2009;104：721-724）
Data on the utility of the waist-to-height ratio in detecting central obesity and related cardiovascular risk among normal weight younger adults are scant. This aspect was examined in 639 normal weight (body mass index 18.5 to 24.9 kg/m(2)) black and white adults (75% white and 36% men) 20 to 44 years old. The subjects with a waist-to-height ratio >= 0.5 were grouped as having central obesity normal weight, with the rest considered the control group. The subjects with central obesity, compared to the controls, after adjusting for age, race, and gender, had significantly greater diastolic blood pressure, mean arterial pressure, low-density lipoprotein cholesterol level, triglycerides, triglycerides/high-density lipoprotein cholesterol ratio, insulin, homeostasis model assessment of insulin resistance, uric acid, C-reactive protein, and liver function enzymes (alanine aminotransferase and T-glutamyl transferase). On multivariate analysis, the central obesity group compared to the control group was 1.9, 2.2, 2.9, and 2.5 times more likely to have significantly adverse levels (top tertile vs the rest) of mean arterial pressure, triglycerides/high-density lipoprotein cholesterol ratio, homeostasis model assessment of insulin resistance, and C-reactive protein, respectively. The central obesity group also had a greater prevalence of dyslipidemia, hypertension, insulin resistance, hyperuricemia, and elevated C-reactive protein. The age-, race-, and gender-adjusted mean value of the common carotid intima-media thickness, a measure of subclinical atherosclerosis, was greater in the central obesity group compared to the control group (0.76 vs 0.71 mm, p = 0.009). In conclusion, these findings underscore the utility of the waist-to-height ratio in detecting central obesity and related adverse cardiovascular risk among normal weight younger adults. (C) 2009 Published by Elsevier Inc. (Am J Cardiol 2009;104:721-724)