Breast cancer risk accumulation starts early: prevention must also.
Breast cancer risk accumulation starts early: prevention must also.
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DOI：
10.1007/s10549-014-2993-8
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发表时间：
2014-06
影响因子：
3.8
通讯作者：
Berkey, Catherine S.
中科院分区：
文献类型：
--
作者：
Colditz, Graham A.;Bohlke, Kari;Berkey, Catherine S.
近四分之一的乳腺癌患者在50岁之前被诊断出来，许多早期的癌前病变已经出现，但尚未被诊断出来。因此，我们回顾了支持乳腺癌预防工作必须在生命早期开始的策略的证据。儿童和青少年时期的暴露会影响女性患乳腺癌的长期风险，但受到的研究关注远远少于生命后期的暴露。乳房组织在初潮和第一次足月妊娠之间经历了快速的细胞增殖，并且风险迅速积累，直到伴随第一次妊娠的终末分化。有证据表明，儿童饮食和身高增长、青少年饮酒以及其他青少年因素与乳腺癌风险和恶性前增生性良性病变风险有关。预防乳腺癌的努力如果在早期开始并持续一生，将会产生最大的效果。认识到知识方面的差距，应加强对其的重视，以开展信息预防。
Nearly 1 in 4 breast cancers is diagnosed before the age of 50, and many early-stage premalignant lesions are present but not yet diagnosed. Therefore, we review evidence to support the strategy that breast cancer prevention efforts must begin early in life. Literature review Exposures during childhood and adolescence affect a woman’s long-term risk of breast cancer, but have received far less research attention than exposures that occur later in life. Breast tissue undergoes rapid cellular proliferation between menarche and first full-term pregnancy, and risk accumulates rapidly until the terminal differentiation that accompanies first pregnancy. Evidence on childhood diet and growth in height, and adolescent alcohol intake, among other adolescent factors are related to breast cancer risk and risk of premalignant proliferative benign lesions. Breast cancer prevention efforts will have the greatest effect when initiated at an early age and continued over a lifetime. Gaps in knowledge are identified and deserve increase attention to inform prevention.
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影响因子：
7.3
作者：
Bombonati, Alessandro;Sgroi, Dennis C.
通讯作者：
Sgroi, Dennis C.
影响因子：
5
作者：
Berkey, CS;Gardner, JD;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
23.9
作者：
Choudhury, Sibgat;Almendro, Vanessa;Polyak, Kornelia
通讯作者：
Polyak, Kornelia
影响因子：
3.8
作者：
Berkey, Catherine S.;Willett, Walter C.;Tamimi, Rulla M.;Rosner, Bernard;Frazier, A. Lindsay;Colditz, Graham A.
通讯作者：
Colditz, Graham A.
DOI：
10.1158/1055-9965.epi-08-1163
发表时间：
2009-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Berkey CS;Colditz GA;Rockett HR;Frazier AL;Willett WC
通讯作者：
Willett WC