Bone formation and osseointegration with titanium implant using granular- and block-type porous hydroxyapatite ceramics (IP-CHA)
Bone formation and osseointegration with titanium implant using granular- and block-type porous hydroxyapatite ceramics (IP-CHA)
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DOI：
10.4012/dmj.2012-169
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发表时间：
2013-10-01
影响因子：
2.5
通讯作者：
Kamata, Nobuyuki
中科院分区：
文献类型：
--
作者：
Minami, Masahiko;Takechi, Masaaki;Kamata, Nobuyuki
本研究的目的是检查互连多孔羟基磷灰石陶瓷（IP-CHA）是否可以作为骨替代物用于重建手术中的植入治疗。我们首先评估了在兔骨缺损模型中，置于颗粒或块状IP-CHA中的钛表面周围是否可以观察到新骨形成。随后，在兔高嵌体移植模型中，研究钛种植体插入块状IP-CHA中的骨结合和稳定性。在兔骨缺损中，发现颗粒或块状IP-CHA中新骨与钛表面直接接触。此外，在嵌贴移植模型中，在块型IP-CHA中发现与种植体表面直接接触的新骨形成，并且术后种植体稳定性商数（ISQ）值显著增加。因此，IP-CHA可能是一种有用的材料，用于重建手术策略中的种植体治疗。
The aim of the present study was to examine whether interconnected porous hydroxyapatite ceramics (IP-CHA) could be used as bone substitute for implant treatment in reconstructive surgery. We firstly assessed if surround of the titanium surface placed into granular or block-type IP-CHA can observe new bone formation in a rabbit bone defect model. Subsequently, osseointegration and stability of titanium implant inserted into block-type IP-CHA was investigated in a rabbit onlay graft model. Direct contact between new bone and the surface of the titanium in granular- or block-type IP-CHA was found in a rabbit bone defect. Further, new bone formation was found in direct contact with the implant surface in the block-type IP-CHA in an onlay graft model, and the implant stability quotient (ISQ) values were significantly increased after surgery. Therefore, IP-CHA may be a useful material for implant treatment in reconstructive surgery strategies.