Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection.
Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection.
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DOI：
10.3389/fmicb.2015.01326
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发表时间：
2015
影响因子：
5.2
通讯作者：
Rizvanov AA
中科院分区：
文献类型：
--
作者：
Muyangwa M;Martynova EV;Khaiboullina SF;Morzunov SP;Rizvanov AA
汉坦病毒是布尼亚病毒科的成员，在小型哺乳动物（主要是啮齿动物）种群中天然存在。这些病毒中的大多数都可以通过接触受污染的动物废物产生的气溶胶或灰尘轻易感染人类。根据所涉及的具体汉坦病毒，人类感染可能导致肾综合征出血热或汉坦病毒心肺综合征。近年来，由汉坦病毒引起的临床病例呈上升趋势。了解汉坦病毒基因组的结构和关键蛋白的功能对于治疗药物的研究至关重要。本文就汉坦病毒核蛋白和糖蛋白的结构和性质作一综述。
Hantaviruses are the members of the family Bunyaviridae that are naturally maintained in the populations of small mammals, mostly rodents. Most of these viruses can easily infect humans through contact with aerosols or dust generated by contaminated animal waste products. Depending on the particular Hantavirus involved, human infection could result in either hemorrhagic fever with renal syndrome or in Hantavirus cardiopulmonary syndrome. In the past few years, clinical cases of the Hantavirus caused diseases have been on the rise. Understanding structure of the Hantavirus genome and the functions of the key viral proteins are critical for the therapeutic agents’ research. This paper gives a brief overview of the current knowledge on the structure and properties of the Hantavirus nucleoprotein and the glycoproteins.