TIR domain-containing adaptors define the specificity of TLR signaling
TIR domain-containing adaptors define the specificity of TLR signaling
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DOI：
10.1016/j.molimm.2003.10.006
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发表时间：
2004-02-01
影响因子：
3.6
通讯作者：
Akira, S
中科院分区：
文献类型：
--
作者：
Yamamoto, M;Takeda, K;Akira, S
Toll样受体（TLR）识别各种病原体中特定分子模式的概念已经建立。在通过TLR的信号转导中，MyD 88（其具有Toll/IL-1受体（TIR）-结构域和死亡结构域）已显示在TLR和MyD 88依赖性下游事件之间连接，导致促炎细胞因子产生和脾细胞增殖。然而，最近使用MyD 88缺陷小鼠的研究表明，一些TLR具有MyD 88非依赖性途径，其代表为LPS刺激诱导的干扰素（IFN）-β产生。这表明TLR信号通路中存在MyD 88以外的其他信号分子。事实上，最近已经鉴定了另外两种含有TIR结构域的衔接子TIRAP/Mal和TRIF。两者都定义了每种TLR的特定生物学反应。(C)2003 Elsevier Ltd.保留所有权利。
The concept that Toll-like receptors (TLRs) recognize specific molecular patterns in various pathogens has been established. In signal transduction via TLRs, MyD88, which harbors a Toll/IL-1 receptor (TIR)-domain and a death domain, has been shown to link between TLRs and MyD88-dependent downstream events leading to proinflammatory cytokine production and splenocyte proliferation. However, recent studies using MyD88-deficient mice have revealed that some TLRs possess a MyD88-independent pathway, which is represented by interferon (IFN)-beta production induced by LPS stimulation. This indicates that additional signaling molecules other than MyD88 exist in the TLR signaling pathway. Indeed, two additional TIR domain-containing adaptors, TIRAP/Mal and TRIF, have recently been identified. Both define the specific biological responses of each TLR. (C) 2003 Elsevier Ltd. All rights reserved.