Effect of Heat Exposure on Aminophylline-Induced Convulsions in Mice
Effect of Heat Exposure on Aminophylline-Induced Convulsions in Mice
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DOI：
10.1248/bpb.34.666
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发表时间：
2011-05-01
影响因子：
2
通讯作者：
Araki, Hiroaki
中科院分区：
文献类型：
--
作者：
Ochi, Rika;Suemaru, Katsuya;Araki, Hiroaki
Theophylline-associated convulsions are frequently exacerbated by fever, but the mechanisms behind it are still not completely understood. We investigated whether N-methyl-D-aspartic acid (NMDA) and gamma aminobutyric acid (GABA) receptors are involved in aminophylline (theophylline-2-ethylenediamine)-induced convulsions that are augmented by heat exposure-induced hyperthermia in mice. Mice exposed to 33 degrees C temperatures for 2 h had significantly increased body temperature (0.94 degrees C). Heat exposure significantly decreased time required for the onset of convulsions induced by an intraperitoneal (i.p.) injection of aminophylline (300 mg/kg). The shortened time for onset of convulsions was blocked by the NMDA receptor antagonist dizocilpine (0.1, 0.3 mg/kg, i.p.). However, the GABA(A) receptor agonist muscimol (1, 2 mg/kg, i.p.) did not have any effect. The pro-convulsant action of NMDA (100-125 mg/kg, i.p.) was enhanced by the heat exposure of 33 C. However, the pro-convulsant actions of picrotoxin (3-4 mg/kg, i.p.), a GABA(A) receptor antagonist, were not affected by increased temperatures. These results suggest that NMDA receptors in the brain play a role in aminophylline-induced convulsions, which are augmented by heat exposure-induced hyperthermia in mice.
