Origin of cardiac fibroblasts and the role of periostin.
Origin of cardiac fibroblasts and the role of periostin.
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DOI：
10.1161/circresaha.109.201400
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发表时间：
2009-11-06
影响因子：
20.1
通讯作者：
Conway SJ
中科院分区：
文献类型：
--
作者：
Snider P;Standley KN;Wang J;Azhar M;Doetschman T;Conway SJ
心脏成纤维细胞是成熟心脏中数量最多的非肌细胞细胞类型，并且是细胞外基质合成和沉积、心脏骨骼生成以及使心房与心室电绝缘所需的。值得注意的是，心脏成纤维细胞也被证明在心脏发育期间的心肌细胞生长和心室腔扩张中起重要作用。虽然目前没有心脏成纤维细胞限制性分子标记物，但通常认为大多数心脏成纤维细胞通过上皮细胞向间充质细胞转化而来源于心外膜。然而，对于心脏成纤维细胞产生的时间和地点、每个细胞的谱系以及心脏成纤维细胞如何移动以驻留在所有四个心腔中的最终位置，仍然知之甚少。在这篇综述中，我们总结了目前的理解，关于骨膜蛋白的功能，一个有用的标记物的非心肌细胞谱系，其作用在心脏形态发生。表征心脏成纤维细胞谱系和鉴定维持、扩展和调节其分化的信号将需要提高我们对正常和病理生理状态下心脏功能的理解。
Cardiac fibroblasts are the most populous non-myocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles. Significantly, cardiac fibroblasts have also been shown to play an important role in cardiomyocyte growth and expansion of the ventricular chambers during heart development. Although there are currently no cardiac fibroblast-restricted molecular markers, it is generally envisaged that the majority of the cardiac fibroblasts are derived from the proepicardium via epithelial-to-mesenchymal transformation. However, still relatively little is known about when and where the cardiac fibroblasts cells are generated, the lineage of each cell, and how cardiac fibroblasts move to reside in their final position throughout all four cardiac chambers. In this review we summarize the current understanding regarding the function of Periostin, a useful marker of the non-cardiomyocyte lineages, and its role during cardiac morphogenesis. Characterization of the cardiac fibroblast lineage and identification of the signals that maintain, expand and regulate their differentiation will be required to improve our understanding of cardiac function in both normal and pathophysiological states.