ARREST OF MOTOR-NEURON DISEASE IN WOBBLER MICE COTREATED WITH CNTF AND BDNF
ARREST OF MOTOR-NEURON DISEASE IN WOBBLER MICE COTREATED WITH CNTF AND BDNF
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DOI：
10.1126/science.8066451
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发表时间：
1994-08-19
期刊：
影响因子：
56.9
通讯作者：
LINDSAY, RM
中科院分区：
文献类型：
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作者：
MITSUMOTO, H;IKEDA, K;LINDSAY, RM
睫状神经营养因子(CNTF)和脑源性神经营养因子(BDNF)各自促进发育中的运动神经元的存活和分化，但它们通过不同的细胞信号通路发挥作用。单独使用任何一种因子都被证明可以减缓但不能阻止摇摆鼠运动神经元功能障碍的进展，摇摆鼠是运动神经元疾病的动物模型。由于CNTF和BDNF已知在体外和体内具有协同作用，因此在同一动物模型中测试了CNTF和BDNF联合治疗的疗效。隔天皮下注射这两种因子可以阻止摇摇鼠的疾病进展1个月，这是通过几项行为、生理和组织学标准来衡量的。
Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) each promote the survival and differentiation of developing motor neurons, but do so through distinct cellular signaling pathways. Administration of either factor alone has been shown to slow, but not to arrest, progression of motor neuron dysfunction in wobbler mice, an animal model of motor neuron disease. Because CNTF and BDNF are known to synergize in vitro and in ovo, the efficacy of CNTF and BDNF cotreatment was tested in the same animal model. Subcutaneous injection of the two factors on alternate days was found to arrest disease progression in wobbler mice for 1 month, as measured by several behavioral, physiological, and histological criteria.