Regulation of human placental development by oxygen tension
Regulation of human placental development by oxygen tension
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DOI：
10.1126/science.277.5332.1669
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发表时间：
1997-09-12
期刊：
影响因子：
56.9
通讯作者：
Fisher, SJ
中科院分区：
文献类型：
--
作者：
Genbacev, O;Zhou, Y;Fisher, SJ
细胞滋养层细胞，专门的胎盘细胞，在怀孕早期增殖，然后分化成肿瘤样细胞，通过侵入子宫及其脉管系统建立胎盘的血流。在这项研究中，在低氧条件下（2%的氧气）培养的细胞滋养层，模仿妊娠10周前子宫表面附近的环境，继续增殖和分化不良。当在20%的氧气中培养时，模拟子宫小动脉附近的环境，细胞停止增殖并正常分化。因此，氧张力决定细胞滋养层细胞是否增殖或侵入，从而调节胎盘生长和细胞结构。
Cytotrophoblasts, specialized placental cells, proliferate early in pregnancy and then differentiate into tumor-like cells that establish blood flow to the placenta by invading the uterus and its vasculature. In this study, cytotrophoblasts cultured under hypoxic conditions (2 percent oxygen), mimicking the environment near the uterine surface before 10 weeks of gestation, continued proliferating and differentiated poorly. When cultured in 20 percent oxygen, mimicking the environment near uterine arterioles, the cells stopped proliferating and differentiated normally. Thus, oxygen tension determines whether cytotrophoblasts proliferate or invade, thereby regulating placental growth and cellular architecture.