HIV-1 superinfection
HIV-1 superinfection
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DOI：
10.1016/j.jaci.2003.08.037
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发表时间：
2003-11-01
影响因子：
14.2
通讯作者：
Altfeld, M
中科院分区：
文献类型：
--
作者：
Allen, TM;Altfeld, M
在过去的一年中，许多报告描述了人类受试者中的HIV-1重复感染，定义为个体再次感染第二种HIV-1异源株。这些报告对初次感染期间产生的HIV-1特异性免疫反应可防止随后感染的假设提出了质疑，并引起了人们的关注，不仅涉及从事不安全性行为的HIV-1阳性者，而且从开发有效疫苗的角度来看。在此，我们回顾了已发表的HIV-1重叠感染的报告，并强调了对HIV-1重叠感染影响全球流行的潜力提供额外见解的研究。
During the past year, a number of reports have described HIV-1 superinfection in human subjects, defined as the reinfection of an individual with a second heterologous strain of HIV-1. These reports have challenged the assumption that HIV-1-specific immune responses generated during primary infection are protective against subsequent infection and have raised concern, not only with respect to HIV-1-positive individuals engaging in unsafe sex but also from the standpoint of developing effective vaccines. Herein we review the published reports of HIV-1 superinfection and highlight studies providing additional insight into the potential for HIV-1 superinfections to affect the global epidemic.