The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitis.
The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitis.
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DOI：
10.1016/j.cld.2012.05.006
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发表时间：
2012-08
影响因子：
5.1
通讯作者：
McCullough AJ
中科院分区：
文献类型：
--
作者：
Pagadala MR;McCullough AJ
非酒精性脂肪肝已成为最常见的慢性肝病。非酒精性脂肪性肝炎（NASH）；更严重的 NAFLD 进展为肝硬化的风险增加。最近，NAFLD 还与心血管发病率和肝外恶性肿瘤风险增加有关，这进一步使这些人因非肝脏相关死亡而导致死亡率增加。现有数据表明，仅患有脂肪变性的个体的病程更为良性，但对于具有晚期组织学严重程度（例如 NASH 和纤维化）的个体来说，发病率和死亡率增加。然而，NAFLD 的自然病程尚未得到精确定义，很大程度上是由于缺乏普遍接受的 NAFLD 组织学定义、肝活检固有的采样误差以及病理学家诊断 NASH 诊断所必需的组织学结果的不一致。尽管存在这些局限性，一些研究已经确定了特定的组织学发现（特别是纤维化，无论分期如何），这些发现能够预测最重要的 NAFLD 相关死亡率。
Nonalcoholic fatty liver disease has emerged as the most prevalent chronic liver disease. Nonalcoholic steatohepatitis (NASH); the more severe form of NAFLD has an increased risk for the progression to cirrhosis. Recently NAFLD has also been linked to the increased risk of cardiovascular morbidity and extrahepatic malignancy, which further predisposes these individuals to increased mortality from non-liver related deaths. The available data suggest a more benign course for individuals with steatosis alone, but increased morbidity and mortality among those with advanced histological severity such as NASH and fibrosis. However, the natural course of NAFLD has yet to be precisely defined in large part due to the lack of universally accepted histologic definition of NAFLD, sampling error intrinsic to liver biopsy, and inconsistency among pathologists to diagnose the histologic findings that are essential to the diagnosis of NASH. Despite these limitations, a few studies have identified specific histologic findings (particularly fibrosis regardless of stage) that are able to predict NAFLD related mortality being most important.
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细胞角蛋白-18片段水平为非酒精性脂肪性肝炎的无创生物标志物：一项多中心验证研究。
影响因子：
13.5
作者：
Feldstein, Ariel E.;Wieckowska, Anna;Lopez, A. Rocio;Liu, Yao-Chang;Zein, Nizar N.;McCullough, Arthur J.
通讯作者：
McCullough, Arthur J.
影响因子：
24.5
作者：
Feldstein AE;Charatcharoenwitthaya P;Treeprasertsuk S;Benson JT;Enders FB;Angulo P
通讯作者：
Angulo P
影响因子：
9.8
作者：
Adams, Leon A.;Harmsen, Scott;St Sauver, Jennifer L.;Charatcharoenwitthaya, Phunchai;Enders, Felicity B.;Therneau, Terry;Angulo, Paul
通讯作者：
Angulo, Paul
影响因子：
4.2
作者：
Fukusato, T;Fukushima, J;Yoshimura, K
通讯作者：
Yoshimura, K
影响因子：
2.9
作者：
Arun, Janani;Jhala, Niraj;Abrams, Gary A.
通讯作者：
Abrams, Gary A.