Prospective Memory Impairments in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates
Prospective Memory Impairments in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates
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DOI：
10.3233/jad-150871
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发表时间：
2016-01-01
影响因子：
4
通讯作者：
Irish, Muireann
中科院分区：
文献类型：
--
作者：
Dermody, Nadene;Hornberger, Michael;Irish, Muireann
背景：前瞻记忆指的是一种面向未来的记忆形式，在这种记忆中，个体必须记住在未来的时间点(基于时间)或对特定事件的反应(基于事件)执行预期的行为。目的：探讨阿尔茨海默病(AD)和行为变异型FTD(BvFTD)中基于时间和事件的PM中断的临床和神经相关性。方法：12名AD、12名bvFTD和12名健康老年对照组参与者完成了剑桥前瞻记忆测验的改良版本，该测验检查了PM的基于时间和事件的方面所有参与者都完成了标准的神经心理学评估并接受了全脑结构磁共振成像。结果：与对照组相比，AD和bvFTD患者在基于时间和基于事件的PM中表现出显著的损害，而在AD组中基于时间的PM受到的影响不成比例。在两组患者中，发作性记忆障碍和海马体萎缩与PM的完整性密切相关，然而，可分离的神经底物也明显影响痴呆综合征的PM表现。结论：我们的研究揭示了神经退行性疾病中PM功能障碍的多方面性质，并提出了共同的和可分离的神经认知机制，这些机制掩盖了每个患者组的这些缺陷。未来对痴呆综合征PM障碍的研究将对开发成功的干预措施以提高患者日常生活的功能独立性至关重要。
Background: Prospective memory (PM) refers to a future-oriented form of memory in which the individual must remember to execute an intended action either at a future point in time (Time-based) or in response to a specific event (Event-based). Lapses in PM are commonly exhibited in neurodegenerative disorders including Alzheimer's disease (AD) and frontotemporal dementia (FTD), however, the neurocognitive mechanisms driving these deficits remain unknown.Objective: To investigate the clinical and neural correlates of Time- and Event-based PM disruption in AD and the behavioral-variant FTD (bvFTD).Methods: Twelve AD, 12 bvFTD, and 12 healthy older Control participants completed a modified version of the Cambridge Prospective Memory test, which examines Time- and Event-based aspects of PM. All participants completed a standard neuropsychological assessment and underwent whole-brain structural MRI.Results: AD and bvFTD patients displayed striking impairments across Time- and Event-based PM relative to Controls, however, Time-based PM was disproportionately affected in the AD group. Episodic memory dysfunction and hippocampal atrophy were found to correlate strongly with PM integrity in both patient groups, however, dissociable neural substrates were also evident for PM performance across dementia syndromes.Conclusion: Our study reveals the multifaceted nature of PM dysfunction in neurodegenerative disorders, and suggests common and dissociable neurocognitive mechanisms, which subtend these deficits in each patient group. Future studies of PM disturbance in dementia syndromes will be crucial for the development of successful interventions to improve functional independence in the patient's daily life.