Advanced Biological Applications of Cerium Oxide Nanozymes in Disease Related to Oxidative Damage
Advanced Biological Applications of Cerium Oxide Nanozymes in Disease Related to Oxidative Damage
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DOI：
10.1021/acsomega.3c03661
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发表时间：
2024-02
期刊：
影响因子：
4.1
通讯作者：
Yandong Bai;Yongmei Li;Yuemei Li;Lijie Tian
中科院分区：
文献类型：
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作者：
Yandong Bai;Yongmei Li;Yuemei Li;Lijie Tian
由于其优异的催化活性，氧化铈纳米颗粒有望作为生物纳米酶。Ce3+离子和Ce4+离子之间发生氧化还原反应，在此期间，它们通过获得或失去电子以及在晶格结构中形成氧空位（或缺陷）而进行转化，这可以充当抗氧化酶并模拟各种酶活性。许多氧化铈纳米颗粒已经被设计成具有多酶活性，包括过氧化氢酶、超氧化物氧化酶、过氧化物酶和氧化酶模拟物特性。氧化铈纳米颗粒具有清除一氧化氮自由基和自由基的特性，并且已经广泛地应用于许多生物学领域，包括生物医学、疾病诊断和治疗。本文综述了氧化铈纳米粒子的催化机制、多种酶活性及其在脑、骨、神经和血管疾病治疗中的潜在应用，沿着。
Due to their excellent catalytic activities, cerium oxide nanoparticles have promise as biological nanoenzymes. A redox reaction occurs between Ce3+ ions and Ce4+ ions during which they undergo conversion by acquiring or losing electrons as well as forming oxygen vacancies (or defects) in the lattice structure, which can act as antioxidant enzymes and simulate various enzyme activities. A number of cerium oxide nanoparticles have been engineered with multienzyme activities, including catalase, superoxide oxidase, peroxidase, and oxidase mimetic properties. Cerium oxide nanoparticles have nitric oxide radical clearing and radical scavenging properties and have been widely used in a number of fields of biology, including biomedicine, disease diagnosis, and treatment. This review provides a comprehensive introduction to the catalytic mechanisms and multiple enzyme activities of cerium oxide nanoparticles, along with their potential applications in the treatment of diseases of the brain, bones, nerves, and blood vessels.