Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology.
Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology.
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DOI：
10.1101/cshperspect.a026492
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发表时间：
2017-07-05
影响因子：
5.4
通讯作者：
Chang HY
中科院分区：
文献类型：
--
作者：
Schmitt AM;Chang HY
虽然只有2%的基因组编码蛋白质，但RNA是从大部分基因序列转录的，这表明大量的细胞功能是在非编码基因组中编程的。哺乳动物基因组含有数万个长的非编码RNA（lncRNA），其中许多发生在疾病相关的基因座或在癌症中特异性表达。尽管绝大多数lncRNA没有已知的功能，但现在在染色质调节和癌症途径中观察到lncRNA的重复分子机制，新兴技术现在提供了询问lncRNA分子相互作用和确定这些丰富的细胞大分子功能的工具。
Although only 2% of the genome encodes protein, RNA is transcribed from the majority of the genetic sequence, suggesting a massive degree of cellular functionality is programmed in the noncoding genome. The mammalian genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which occur at disease-associated loci or are specifically expressed in cancer. Although the vast majority of lncRNAs have no known function, recurring molecular mechanisms for lncRNAs are now being observed in chromatin regulation and cancer pathways and emerging technologies are now providing tools to interrogate lncRNA molecular interactions and determine function of these abundant cellular macromolecules.